Bregman went 2-for-4 in Wednesday's 1-0 loss to the Mariners.
Bregman's second hit came in the ninth inning, and he was removed for a pinch runner, an indication that the Astros are being overly cautious with the infielder who is just returning from a lengthy stay on the injured list due to a quadriceps injury. The run was deemed important at the time, and manager Dusty Baker didn't want to risk Bregman pushing it and aggravating the injury.