Reed, who was recalled from the minors on Tuesday, went 0-for-4 with a strikeout during Houston's 2-1 loss to Toronto.
Reed carried a lot of hype in spring training, but ultimately lost the Astros' first base competition to Tyler White and has yet to make an impact in 18 games with the big league club this season. The 23-year-old figures to platoon with White at first base while Luis Valbuena (hamstring) is on the DL. Expect him to start Wednesday when the Astros square off against right-hander Marco Estrada, but sit Thursday against lefty J.A. Happ.