Monday, October 6, 2025
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| R. PearsallRicky Pearsall | WR | Mon, Oct 6 | Knee - PCL | Questionable for Week 6 at Tampa Bay |
| J. WatkinsJordan Watkins | WR | Mon, Oct 6 | Calf | Questionable for Week 6 at Tampa Bay |
| R. Beal Jr.Robert Beal Jr. | DE | Mon, Oct 6 | Ankle | Questionable for Week 6 at Tampa Bay |
| B. PurdyBrock Purdy | QB | Mon, Oct 6 | Toe | Questionable for Week 6 at Tampa Bay |
| J. JenningsJauan Jennings | WR | Mon, Oct 6 | Ankle | Questionable for Week 6 at Tampa Bay |
Friday, October 3, 2025
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| A. CollinsAlfred Collins | DT | Fri, Oct 3 | Knee | Questionable for Week 6 at Tampa Bay |
| K. DavisKalia Davis | DT | Fri, Oct 3 | Hand | Doubtful for Week 6 at Tampa Bay |
| G. KittleGeorge Kittle | TE | Fri, Oct 3 | Hamstring | IR. Injured Reserve. Expected Return - Week 7 |
| Y. Gross-MatosYetur Gross-Matos | DE | Fri, Oct 3 | Hamstring | Doubtful for Week 6 at Tampa Bay |
| U. StoutUpton Stout | CB | Fri, Oct 3 | Ankle | Questionable for Week 6 at Tampa Bay |
Thursday, October 2, 2025
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| K. GivensKevin Givens | DT | Thu, Oct 2 | Pectoral | IR. Injured Reserve. Expected Return - Week 6 |
| K. RourkeKurtis Rourke | QB | Thu, Oct 2 | Knee | NFI-R for Week 6 at Tampa Bay |
| J. CowingJacob Cowing | WR | Thu, Oct 2 | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
Wednesday, October 1, 2025
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| T. TaylorTrent Taylor | WR | Wed, Oct 1 | Undisclosed | IR. Injured Reserve |
| M. MustaphaMalik Mustapha | SAF | Wed, Oct 1 | Knee - ACL | Physically Unable to Perform. Expected Return - Week 6 |
| J. RobinsonJakob Robinson | CB | Wed, Oct 1 | Forearm | IR. Injured Reserve |
| T. Hodges-TomlinsonTre'Vius Hodges-Tomlinson | CB | Wed, Oct 1 | Undisclosed | IR. Injured Reserve |
| B. AiyukBrandon Aiyuk | WR | Wed, Oct 1 | Knee - ACL + MCL | Physically Unable to Perform. Expected Return - Week 6 |
| T. JacksonTarron Jackson | DE | Wed, Oct 1 | Undisclosed | IR. Injured Reserve |
| P. TaylorPatrick Taylor | RB | Wed, Oct 1 | Shoulder | IR. Injured Reserve |
Saturday, September 20, 2025
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| S. BurfordSpencer Burford | OT | Sat, Sep 20 | Knee | IR. Injured Reserve. Expected Return - Week 7 |
Wednesday, September 17, 2025
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| B. BartchBen Bartch | OT | Wed, Sep 17 | Ankle | IR. Injured Reserve. Expected Return - Week 7 |