Warner (ankle) will undergo season-ending surgery Tuesday, Nick Wagoner of ESPN.com reports.
Coach Kyle Shanahan said the hope is Warner will be ready in time for training camp next summer after he suffered a dislocated and fractured ankle in Sunday's loss to the Bucs. Tatum Bethune projects to full Warner's hole in the defense moving forward this season, but the 49ers could look for outside reinforcements on defense after losing both Warner and Nick Bosa (knee) to season-ending injuries.
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49ers' Tatum Bethune: Impresses in larger role
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Bethune recorded 10 total tackles (five solo) during Sunday's 30-19 loss to the Buccaneers.
The second-year pro from Florida State had played just three defensive snaps all season prior to Fred Warner's (ankle) injury in the first quarter of Sunday's loss. Bethune made the most of his opportunity, finishing with a career-high and team-leading 10 total tackles across 42 defensive snaps in Week 6. With Warner expected to miss substantial time, Bethune is likely to step in as the 49ers' starting middle linebacker for the remainder of the season.
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49ers' Fred Warner: Done for year
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Head coach Kyle Shanahan told reporters after Sunday's 30-19 loss to the Buccaneers that Warner will undergo season-ending surgery on his right ankle, Nick Wagoner of ESPN.com reports.
Warner was carted off the field during the first quarter of Sunday's game. Further tests revealed that the veteran linebacker dislocated and broke his right ankle, and he will undergo surgery to repair the injuries and be sidelined for the rest of the 2025 campaign. Warner logged one tackle prior to his exit, and the 2018 third-rounder's season will end with him accumulating 51 tackles (28 solo), three pass defenses, two forced fumbles and one fumble recovery over six games. The 49ers will turn to Tatum Bethune and Curtis Robinson to fill in the gap at linebacker left by Warner. Rookie third-rounder Nick Martin has been a healthy scratch for each of the first six games of the regular season, but he could be active and make his NFL debut in San Francisco's Week 7 clash against Atlanta on Sunday, Oct. 19.
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49ers' Fred Warner: Suffers dislocated ankle
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Warner dislocated his right ankle in the first quarter of Sunday's game against the Buccaneers, Dianna Russini of The Athletic reports.
Warner suffered the injury during the first quarter and was quickly ruled out after he was carted to the locker room. He'll undergo further tests and meet with doctors to determine how much time he'll miss, but the loss of Warner is a big blow to a 49ers defense that is already without Nick Bosa (knee) for the rest of the season. Tatum Bethune and Curtis Robinson will continue to see more snaps at linebacker in Warner's absence.
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49ers' Fred Warner: Ruled out vs Tampa Bay
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Warner (ankle) will miss the remainder of San Francisco's matchup versus the Buccaneers on Sunday, Jennifer Lee Chan of NBC Sports reports.
Warner was carted off the field in the first quarter and was quickly ruled out for the remainder of the game. With there's currently no timetable for the 28-year-old's return, he could be forced to miss an extended period of time. In Warner's absence, Tatum Bethune and Curtis Robinson could be in line for increased playing time.
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49ers' Upton Stout: Cleared to play Week 6
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Stout (ankle) is active for Sunday's game against the Buccaneers, Briana Jeannel of the 49ers' official site reports.
Stout was limited in practice all week due to an ankle injury that he picked up during the 49ers' Week 5 win over the Rams, but the rookie third-rounder was given the green light to play in Sunday's road tilt. Stout has 20 tackles (10 solo), including 1.0 sacks, and two pass defenses through the first five regular-season games of his NFL career.
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49ers' Alfred Collins: Set to play vs. Tampa Bay
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Collins (knee) will play in the 49ers' matchup versus the Buccaneers on Sunday, Briana Jeannel of the team's official site reports.
Collins suffered a sprained knee in the Week 5 win over the Rams but is now healthy again. The rookie second-round pick has recorded just five tackles (two solo) across his first five outings while playing on both defense and special teams. He should continue to serve as a depth option along the defensive line in Sunday's game.
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49ers' Malik Mustapha: Cleared to make 2025 debut
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Mustapha (knee) is active for Sunday's game against the Buccaneers, Briana Jeannel of the 49ers' official site reports.
Mustapha is ready to make his 2025 debut after fully recovering from a torn ACL that he suffered in January. With how well rookie fifth-rounder Marques Sigle has been playing this season, Mustapha may work in a rotational role in the secondary and on special teams in his return.
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49ers' Kalia Davis: Will play Sunday
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Davis (hand) is active for San Francisco's matchup versus Tampa Bay on Sunday, Briana Jeannel of the team's official site reports.
Davis is set to play despite recently undergoing surgery to repair a broken hand suffered in the Week 5 win over the Rams. The 27-year-old should return to his role as one of the team's starting defensive tackles alongside Jordan Elliott for Sunday's game.
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49ers' Malik Mustapha: Activated off IR
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The 49ers activated Mustapha (knee) off injured reserve Saturday.
Mustapha is closer to making his return after recovering from a torn ACL. While he remains questionable for Sunday's game versus Tampa Bay, the 23-year-old should serve as a depth defensive back and can also contribute on special teams if he ends up playing.
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49ers' Robert Beal: Good to go for Week 6
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Beal (groin) doesn't carry an injury designation into Sunday's game against Tampa Bay, Greg Auman of Fox Sports reports.
After logging a pair of DNPs Wednesday and Thursday, Beal was removed from the injury report entirely Friday and appears to be ready to play after missing Week 5. Beal has appeared in just one game this season, seeing action on 12 defensive snaps and another 18 on special teams.
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49ers' Malik Mustapha: Completes week of full practice
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Mustapha (knee) is listed as questionable for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports.
Mustapha is working his way back from a torn ACL and had his practice window opened Monday. He practiced in full the entire week, so he should have a strong chance to make his 2025 debut against Tampa Bay.
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49ers' Alfred Collins: Iffy for Week 6
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Collins (knee) is questionable for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports.
Collins suffered a sprained knee in Week 5 but managed to turn in limited practices both Thursday and Friday. He appears to be truly questionable for Week 6, and his status will be important given that he's logged a minimum of one-third of defensive snaps from Week 2 on.
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49ers' Yetur Gross-Matos: Officially ruled out
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Gross-Matos (hamstring) will not play in Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports.
Gross-Matos suffered a hamstring injury in San Francisco's Week 5 win. Despite having a few extra days to recover, he was unable to practice in any capacity during the week.
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49ers' Kevin Givens: Won't return for Week 6
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Givens (pectoral) is out for Sunday's game against Tampa Bay, Greg Auman of Fox Sports reports.
Givens has yet to play this season but was designated to return from injured reserve Wednesday. He managed to log three limited sessions, so a Week 7 season debut could be realistic for Givens.
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49ers' Alfred Collins: Sidelined by knee injury
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Collins (knee) did not practice Wednesday, Eric Branch of the San Francisco Chronicle reports.
Collins suffered a knee sprain in Thursday's win over the Rams, so it's not a big surprise that he was unable to practice to begin preparation for a Week 6 matchup against Tampa Bay. Kalia Davis (hand) will also be sidelined, so the 49ers' defensive line could be shorthanded.
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49ers' Upton Stout: Manages partial practice
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Stout (ankle) was a limited practice participant Wednesday, Eric Branch of the San Francisco Chronicle reports.
Stout suffered a sprained ankle in Thursday's win over the Rams and was considered day-to-day at the time. His ability to practice at all is a positive sign, but his status for San Francisco's Week 6 game against Tampa Bay remains unclear.
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49ers' Malik Mustapha: Logs full session
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Mustapha (knee) practiced fully Wednesday, Eric Branch of the San Francisco Chronicle reports.
Mustpaha is recovering from a torn ACL and had his practice window opened Monday. He has three weeks to be activated from injured reserve, so while his full practice participation is a positive sign, it's not indicative that Mustapha will be ready for his season debut in Week 6 against Tampa Bay.
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49ers' Kevin Givens: Practice window opened
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The 49ers designated Givens (pectoral) to return from injured reserve Wednesday.
Givens suffered a pectoral injury in early August during training camp, which was severe enough for him to open the 2025 regular season on injured reserve. He's progressed enough in his recovery for the 49ers to open his 21-day practice window, and the seventh-year defensive tackle was a limited participant in Wednesday's session, per Eric Branch of the San Francisco Chronicle. Even with his return to practice, Givens is far from a guarantee to play against the Buccaneers on Sunday.
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49ers' Malik Mustapha: Practice window opened
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The 49ers opened Mustapha's (knee) 21-day practice window to return from the reserve/PUP list.
Mustapha is ready to take the next step in his recovery from a knee injury that he suffered in January, which caused him to open the 2025 regular season on the PUP list. Mustapha will return to practice this week and could be reinstated from the PUP list ahead of Sunday's game against the Buccaneers, though that will depend on his participation level in practice. The 2024 fourth-rounder logged 72 tackles (32 solo) and five pass defenses (including one interception) across 16 regular-season games during his rookie season.
