Dupree (neck) has been ruled out for the remainder of Sunday's game against the Broncos.
Dupree exited the third quarter of Sunday's contest with a neck injury. The linebacker was originally questionable to return, but after extended evaluation, the injury has apparently been deemed severe enough to eliminate Dupree from the rest of the Chargers' divisional showdown with the Broncos.
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Chargers' Bud Dupree: Exits with neck injury
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Dupree (neck) is questionable to return to Sunday's game against the Broncos.
Dupree exited the third quarter of Sunday's contest with a neck injury. Akheem Mesidor will be the sole rotational option at outside linebacker while Dupree is evaluated.
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Chargers' Rodney Shelley: Inactive in Week 5
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Shelly (hamstring) is inactive for Sunday's game versus the Broncos, Eric Smith of the team's official site reports.
Shelly has been dealing with the hamstring injury for at least a few weeks. After suiting up in the Chargers' first four games of the 2026 campaign, he will finally sit out in Week 5 against Denver.
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Chargers' Scott Matlock: Active versus Denver
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Matlock (foot) is active for Sunday's game against the Broncos, Eric Smith of the team's official site reports.
Matlock was activated off injured reserve Saturday, so despite carrying a questionable designation, most assumed he would be back on the field after sitting out the first four games of the 2026 campaign.
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Chargers' Scott Matlock: Taken off injured reserve
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The Chargers activated Matlock (foot) from injured reserve Saturday, but he's still listed as questionable for Sunday's game against the Broncos.
Matlock was designated to return from injured reserve Wednesday, and he drew the questionable tag after logging a full practice Friday. The fact that he was activated from IR indicates that Matlock has a good chance of making his 2026 regular-season debut Sunday.
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Chargers' Dalvin Tomlinson: Returning for Week 5
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Tomlinson (hamstring) doesn't have an injury designation for Sunday's game against the Broncos.
A hamstring injury has sidelined Tomlinson for the Chargers' last two games, but he avoided an injury tag for Sunday's AFC West tilt after logging a full practice Friday. He'll solidify the Chargers' depth on the defensive line behind Jamaree Caldwell, Teair Tart and Justin Eboigbe.
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Chargers' Derwin James: Ruled out for Week 5
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James (hamstring) has been ruled out against the Broncos on Sunday.
James will miss a second consecutive game due to a hamstring injury. He has been unable to practice since picking up the injury and is considered week-to-week, so it remains to be seen whether he'll be available to return for Week 6 against the Chiefs on Sunday, Oct. 18. Elijah Molden, Genesis Smith and Tony Jefferson will all step into larger roles in the secondary in James' absence.
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Chargers' Donte Jackson: Won't play versus Denver
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Jackson (hamstring) has been ruled out for Sunday's game against the Broncos.
Jackson was held out of practice all week due to a hamstring injury, which he picked up during the Chargers' Week 4 loss to the Seahawks. His next chance to play is Week 6 against the Chiefs, but in his absence, Deane Leonard and Rodney Shelley are the top candidates to start at outside cornerback opposite Cam Hart.
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Chargers' Donte Jackson: Misses practice Wednesday
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Jackson (hamstring) did not practice Wednesday, Kris Rhim of ESPN.com reports.
Jackson was in concussion protocol and listed as questionable ahead of the Week 4 meeting with Seattle. While he managed to get on the field, he exited the contest due to a hamstring issue and didn't return. It's possible Jackson didn't practice Wednesday as a precaution, so he'll have a few more chances to get out there. For now, the 30-year-old should at least be considered questionable for the Week 5 matchup with Denver.
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Chargers' Tuli Tuipulotu: Secures interception in loss
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Tuipulotu recorded six total tackles (three solo), including 0.5 sacks, while intercepting a pass and forcing a fumble during Sunday's 30-23 loss to Seattle.
Tuipulotu jumped in front of quarterback Sam Darnold's first pass of the day, notching his first career interception. The linebacker later stripped running back Emanuel Wilson in the third quarter, but Wilson fell on the fumble. Tuipulotu also combined with defensive lineman Justin Eboigbe to sack Darnold in the fourth quarter. The 24-year-old has now compiled 18 total tackles (11 solo), including 2.0 sacks, while also adding an interception and a forced fumble over four contests this season.
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Chargers' Derwin James: Considered week-to-week
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James (hamstring) is considered week-to-week ahead of the team's Week 5 matchup with Denver, Alex Insdorf of BoltBeat.com reports.
James was unavailable for Sunday's 30-23 loss to Seattle while nursing a hamstring issue, and head coach Jim Harbaugh outlined that the safety may need to miss more action moving forward. James was a limited participant at practice throughout the last week, and he'll likely have to log a full practice in order to avoid an injury designation before the team's contest against the Broncos in Week 5.
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Chargers' Donte Jackson: Cleared to play Sunday
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Jackson (concussion) is available for Sunday's game against Seattle.
Jackson was in the league's concussion protocol. However, after practicing in full Friday, he will suit up for the Week 4 meeting with the Seahawks.
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Chargers' Elijah Molden: Available to play Sunday
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Molden (hamstring) is available for Sunday's game against Seattle.
Molden has been battling a hamstring injury but will avoid another absence in Week 4. As a result, RJ Mickens and Genesis Smith should see fewer snaps.
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Chargers' Donte Jackson: Tagged as questionable after full practice
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Jackson (concussion) is listed as questionable for Sunday's game against the Seahawks.
Jackson entered the league's concussion protocol during the Chargers' Week 3 loss to the Bills. He progressively increased his practice participation this past week, culminating in a full session Friday, but Jackson will need to pass an evaluation by an independent neurologist in order to be cleared to play against Seattle.
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Chargers' Elijah Molden: Chance to return vs. Seattle
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Molden (hamstring) is listed as questionable for Sunday's game against the Seahawks.
A hamstring injury prevented Molden from playing against the Bills in Week 3, but the sixth-year pro drew the questionable tag for Week 4 after logging three consecutive limited practices. One or both of Tony Jefferson and Genesis Smith could start at safety Sunday depending on the statuses of both Molden and Derwin James (hamstring).
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Chargers' Derwin James: Tagged as questionable vs. Seattle
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James (hamstring) is questionable for Sunday's game against the Seahawks.
James posted an LP-DNP-LP practice log while working through a hamstring injury that he likely picked up during the Chargers' Week 3 loss to the Bills. Elijah Molden (hamstring) is also listed as questionable, so Tony Jefferson and Genesis Smith would both be in line for more defensive snaps if one or both of James and Molden were to be ruled out.
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Chargers' Derwin James: Doesn't practice Thursday
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James (hamstring) was a non-participant in practice Thursday.
Thursday's DNP represents a downgrade for James after he was a limited practice participant Wednesday. However, the Chargers' practice report lists the star safety as being sidelined due to both a hamstring injury and "rest," so it's unclear how serious the hamstring issue is. Los Angeles' practice report Friday should shed more light on James' chance of suiting up in Week 4.
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Chargers' Donte Jackson: Limited practice Thursday
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Jackson (concussion) was a limited participant at the Chargers' practice Thursday.
Jackson suffered a concussion in the team's 24-16 loss to the Bills in Week 3, and he was considered a non-participant at Wednesday's practice. His ability to return to practice Thursday is a step in the right direction, but he still has to clear concussion protocol before he'd be eligible to play Sunday versus Seattle.
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Chargers' Tuli Tuipulotu: Sacks quarterback in loss
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Tuipulotu logged six tackles (five solo), including 1.5 sacks, in the Chargers' 24-16 loss to the Bills on Sunday.
Tuipulotu played 82 percent of the Chargers' defensive snaps in Sunday's loss. The outside linebacker sacked Allen once and participated in another sack while the Chargers' defense notched five turnovers in a losing effort. The 24-year-old's 1.5 sacks were his first of the season, logging zero in Week 1 and Week 2.
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Chargers' Genesis Smith: Two picks in loss
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Smith accumulated five tackles (two solo) and two passes defensed for two interceptions in the Chargers' 24-16 loss to the Bills on Sunday.
Smith had a stellar defensive night, picking off superstar quarterback Josh Allen twice while the Chargers defense amassed five turnovers. Smith picked off Allen at the Buffalo 43-yard line in the first quarter and the Chargers' 10-yard line on a bobbling grab that landed in his chest during the second quarter. The free safety was starting due to the absence of Elijah Molden (hamstring) but held up well in coverage and made the Bills pay for testing him so frequently.
