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While home favorites have won 73.8% of games, straight up, this season, their spread record isn't quite as decisive. Home favorites have covered in 55% of games, which is information you could use when making Week 8 NFL bets. There are just three road favorites on the Week 8 NFL schedule, as home teams giving points include the Ravens (-6.5) versus the Bears, the Eagles (-7) against the Giants, the Broncos (-3.5) as they host the Cowboys, and the Colts (-14) when they take on the Titans. A thorough Week 8 NFL betting guide would observe the trends around the league, allowing you to be fully informed before making NFL predictions.

Meanwhile, one of those three road favorites is Green Bay (-3) as it will visit old friend, Aaron Rodgers, and Pittsburgh on Sunday night. Which side of the Week 8 NFL odds should you back in this contest, and should your Week 8 NFL picks include Rodgers, Jordan Love, D.K. Metcalf or Josh Jacobs within Fantasy football lineups or as part of NFL player props? If you are looking for NFL picks, NFL parlays, Fantasy football rankings or NFL DFS picks for Week 8, SportsLine has you covered with its proven model, Machine Learning Model and team of experts. Join SportsLine here, and for a limited time get your first month for $1 using promo code CHAMPIONSHIP. 

NFL parlay picks could generate massive payouts

SportsLine's model has returned well over $7,000 on top-rated NFL betting picks since its inception, so those picks can confidently be used to fill out NFL parlay picks on betting apps. The model has built a five-team parlay for Week 8 that pays 25-1, and one of the legs is the Philadelphia Eagles (-7, 44) covering against the Giants. The model has Philadelphia covering in well over 50% of simulations, and the rest of the five-team parlay can be found here.

You can also bet this parlay at DraftKings, where you can get $300 in bonus bets + 3 months of NBA League Pass if your initial $5 wager wins

NFL DFS picks from top experts 

SportsLine has a DFS Optimizer that simulates every game 10,000 times and uses info from the SportsLine Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on sites like FanDuel and DraftKings. It has the Broncos' Bo Nix as one of its top value picks at quarterback, while the Colts' Michael Pittman is among the best values at wide receiver for Sunday's main slate. Here are its complete Week 8 NFL DFS rankings

Senior Fantasy Writer Heath Cummings has locked in his projections for every Fantasy relevant quarterback, running back, wide receiver and tight end. Not only do you get statistical projections as well as Fantasy point totals for every player in different scoring formats, but Cummings also includes DFS prices and values to help build winning DFS lineups each week. He has Baltimore's Zay Flowers as a top-3 Fantasy wideout in both standard and PPR formats. Get his full Week 8 Fantasy and DFS projections right here

New users can also make picks at Underdog and get $100 in site credits after making a $5 wager:

Fantasy rankings to help you win your matchups

SportsLine's model simulates every game 10,000 times, which has helped it produce better Fantasy rankings than human experts over the last few seasons. It has revealed its Week 8 Fantasy football rankings that can be used to make start-sit decisions. The Panthers' Tetairoa McMillan is projected to be a top-12 Fantasy receiver this week, and the model also has full rankings for every position right here

Advanced NFL model simulates every game 10,000 times 

SportsLine's model enters Week 8 of the 2025 NFL season up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 43-28 run on top-rated picks dating back to 2024 and has revealed picks for every Week 8 NFL game. One of its favorite picks is the Browns (+7) covering versus New England, which cashes well over 50% of the time. You can find the model's picks for every NFL Week 8 game here

You can also use the latest FanDuel promo code to get $300 in bonus bets instantly:

NFL Vegas expert picks revealed 

SportsLine has an expansive team of NFL experts who provide quality betting advice for every game on the schedule. Analyst R.J. White, who is 34-25 (+779) over his last 59 ATS picks, has revealed his Week 8 best bets. He is backing the 49ers (+1.5) to cover at Houston, saying, "The Texans have seen exactly two scenarios this season: dominate an uncompetitive roster (Titans, beat-up Ravens) and generate no offense against everyone else... With Nico Collins suffering a concussion in the wee hours of Tuesday morning, he's unlikely to be available here, so I don't know how Houston scores points. I see the 49ers closing as favorites in this game." White's NFL best bets for Week 8 can be found here.

Eric Cohen, who is 60-32-1 (65%) on his straight-up NFL picks this season, has exact score predictions for all 13 games. He is high on the Eagles (-7, 43.5) to defeat the Giants, 28-18, on Sunday. Hit any of his exact score picks and you're looking at a payout well over 100-1. That pick, along with his prediction for every game, is available here.

Chargers vs. Vikings 'Thursday Night Football' picks

A pair of three-loss teams both coming off defeats will meet on TNF as the Chargers (-3) host the Vikings. Justin Herbert leads the NFL in passing yards, while Carson Wentz remains under center for the injured J.J. McCarthy. SportsLine AI predicts that Chargers wideout Ladd McConkey will go Over 5.5 receptions, projecting he has 7.0 catches in a 4-star prop pick. NFL expert Emory Hunt, who is 19-6 (+1271) over his last 25 Chargers picks, says this is a "get right" game for one defense. See Hunt's Vikings vs. Chargers picks here.

Steelers vs. Packers 'Sunday Night Football' picks

Aaron Rodgers will line up against his former team for the first time as Pittsburgh hosts the Packers on Sunday night. The four-time MVP has defeated 31 NFL teams, with his former employer the one that's missing. Green Bay is a 3-point road favorite though the Pack have dropped four straight versus the spread. The total is 44.5, and SportsLine's model has the Over hitting, with the teams projected for 47 combined points. The model also has an A-rated money line prediction, in addition to its spread pick. See Packers vs. Steelers picks from the advanced model here.

Chiefs vs. Commanders 'Monday Night Football' picks

The Chiefs are back on primetime after a rare 1 p.m. ET kickoff last week, in which they shut out the Raiders 31-0. Meanwhile, the Commanders lost to Dallas on Sunday, 44-22, and lost Jayden Daniels to a hamstring injury. His status will be one to follow up until kickoff as he deals with his second lower-body injury of the year. Meanwhile, the SportsLine model projects Patrick Mahomes to have have nearly 300 passing yards with multiple touchdowns through the air. The proven model has also made its spread, money line and total picks for Monday Night Football. See Commanders vs. Chiefs picks from the model here.