Week 15 NFL odds, lines, best bets, predictions: Computer model backing Giants and Saints

If ever a day deserved to be called Statement Sunday, it's the one that takes place during the Week 15 NFL schedule. There are no fewer than five matchups to make Week 15 NFL predictions on with major playoff implications for both teams. This includes divisional contests like Chiefs vs. Chargers (+4.5) and Patriots vs. Bills (-1.5). Additionally, there are captivating non-divisional games to make NFL best bets on such as Packers vs. Broncos (+2.5) and Lions vs. Rams (-5.5).

While those games all have close NFL spreads, there are some wider ones featuring playoff contenders versus teams contending for high positions in the NFL Draft. The Week 15 NFL odds have the Eagles favored by 12.5 points over the Raiders, while the 49ers are 12.5-point favorites against the Titans. All of the updated Week 15 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 15 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 on a 50-35 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, it has turned its attention to the latest Week 15 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick. 

Top Week 15 NFL predictions

We can tell you one of the model's strongest Week 15 NFL picks is that the Saints (+3, 40.5) cover versus Carolina in a Sunday 4:25 p.m. ET kickoff in well over 60% of simulations. The Saints pulled off a road upset victory on Sunday over Tampa, covering for the second straight and for the third time in the last four games. QB Tyler Shough is providing a running element that Spencer Rattler didn't, as the rookie had 55 yards and two scores on the ground versus the Bucs. Bet the Saints to go Over 9.5 first-half points at DraftKings:

New Orleans also has an underrated pass defense, ranking sixth in the NFL, while Carolina already struggles on offense. The Panthers are in the bottom 10 in points scored, total yards and redzone scoring, and they have just one victory, as well as one cover, over their last five versus the Saints. The model also has the Over hitting in over 60% of simulations in an A-rated pick. See which other teams to pick here, and bet the Saints to cover at DraftKings right here:

Another one of its Week 15 NFL predictions: the Giants (-2.5, 47.5) cover versus the Commanders in a Sunday kickoff at 1 p.m. ET. Jayden Daniels re-injured his elbow in Sunday's shocking 31-0 loss to Minnesota, leaving the game in the third quarter and not returning. While his availability is unknown to face the Giants, Zach Ertz (ACL) is now done for the year. That's a big blow to a passing offense which is already a bottom-10 unit, while Washington ranks in the bottom-five in points allowed, yards allowed, run defense and pass defense. Both Washington (eight) and New York (seven) are on lengthy losing streaks, but the Giants have a 4-3 spread record during their streak, while the Commanders are just 1-7 ATS on theirs. New York is projected to cover in over 50% of simulations. See which other teams to pick here, and bet the Giants to cover at DraftKings:

How to make Week 15 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 15 NFL schedule and just revealed three underdogs projected to outright win, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.

So what Week 15 NFL picks can you make with confidence, and which three underdogs should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.

Week 15 NFL betting odds, lines, live spreads, scores

Get Week 15 NFL picks at SportsLine