Week 13 NFL betting guide, props, spreads: Model, expert, parlay, DFS and season-long fantasy picks revealed
SportsLine's team of Vegas experts and its proven model and experts to get you ready for Week 13 NFL betting

Some quality Week 13 NFL betting advice would be to consider anything and everything before placing Week 13 NFL predictions. How teams perform versus the spread on a short week is pertinent for this week's slate, as are how teams perform in adverse conditions or with lengthy travel, which are also relevant with this week's NFL schedule. A dome team in Atlanta has to travel to NYC to face the Jets, as the former may have to deal with the elements. Meanwhile, the Rams, who are the biggest favorites per the Week 13 NFL odds at -10.5, will have to travel cross country to Carolina for a 1 p.m. ET Sunday kickoff.
Those are things outside of the NFL spread records one should consider before laying down any wagers. Along with the Rams, other double-digit favorites include the Seahawks (-11.5) versus the Vikings and the Chargers (-10) against the Raiders. The heavily favored teams feature the likes of Matthew Stafford, Kyren Williams, Jaxon Smith-Njigba and Justin Herbert who could factor into NFL player props, plugged into Fantasy football lineups or be a part of your NFL DFS strategy. If you are looking for NFL picks, NFL parlays, Fantasy football rankings or NFL DFS picks for Week 13, SportsLine has you covered with its proven model, Machine Learning Model and team of experts.
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NFL parlay picks could generate massive payouts
SportsLine's model has returned well over $7,000 on top-rated NFL betting picks since its inception, so those picks can confidently be used to fill out NFL parlay picks on betting apps. The model has built a five-team parlay for Week 13 that pays 25-1, and one of the legs is the Rams (-10.5, 45) covering against the Panthers. The model has Los Angeles covering in nearly 60% of simulations in an A-rated pick, and the rest of the five-team parlay can be found here.
NFL DFS picks from top experts
SportsLine has a DFS Optimizer that simulates every game 10,000 times and uses info from the SportsLine Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on sites like FanDuel and DraftKings. It has the Jags' Trevor Lawrence as one of its top value picks at quarterback, while Las Vegas' Ashton Jeanty is among the best values at running back for Sunday's main slate. Here are its complete Week 13 NFL DFS rankings.
Senior Fantasy Writer Heath Cummings has locked in his projections for every Fantasy relevant quarterback, running back, wide receiver and tight end. Not only do you get statistical projections as well as Fantasy point totals for every player in different scoring formats, but Cummings also includes DFS prices and values to help build winning DFS lineups each week. He has the Browns' Harold Fannin Jr. as a top-10 Fantasy tight end this week. Get his full Week 13 Fantasy and DFS projections right here.
New users can also make picks at Underdog and get $100 in site credits after making a $5 wager:
Fantasy rankings to help you win your matchups
SportsLine's model simulates every game 10,000 times, which has helped it produce better Fantasy rankings than human experts over the last few seasons. It has revealed its Week 13 Fantasy football rankings that can be used to make start-sit decisions. The Texans' Woody Marks is projected to be a top-20 Fantasy running back this week, and the model also has full rankings for every position right here.
Advanced NFL model simulates every game 10,000 times
SportsLine's model is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 on a 49-33 run on top-rated picks dating back to 2024 and has revealed picks for every Week 13 NFL game. One of its favorite picks is the Falcons (-2.5, 39.5) covering versus the Jets, which cashes nearly 60% of the time. You can find the model's picks for every NFL Week 13 game here.
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NFL Vegas expert picks revealed
SportsLine has an expansive team of NFL experts who provide quality betting advice for every game on the schedule. Larry Hartstein, who is 24-18-1 (+386) over his last 43 NFL ATS picks, is backing Indianapolis (-3.5) to cover at home versus Houston on Sunday.
"The Colts haven't played at home since Oct. 26, when they destroyed Tennessee 38-14. They're a different offense inside, on an artificial surface. This is the one of the only 3.5s left in the market, as money is pouring in on the Colts. Houston's elite defense isn't quite as tough on the road. Lay the points." Hartstein's NFL best bets for Week 13 can be found here.
Thanksgiving Day NFL picks
The Thanksgiving Day NFL slate features Lions vs. Packers (+2.5), Cowboys vs. Chiefs (-3) and Ravens vs. Bengals (+7). SportsLine's model, which is up well over $7,000 for $100 players on top-rated NFL picks since its inception, has identified a four-leg parlay that returns over 11-1. One of the parlay legs is Baltimore (-7) covering versus Cincinnati, which hits in well over 50% of simulations in an A-rated pick. See the rest of the NFL Thanksgiving parlay picks here.
DFS expert, Mike McClure, who has more than $2 million in career winnings in daily Fantasy, has his top NFL DFS picks for the Thanksgiving Day NFL games. He likes Kansas City tight end, Travis Kelce, and Cincinnati running back, Chase Brown, as options you should insert into your NFL DFS lineups. See the rest of McClure's Thanksgiving DFS picks here.
Bears vs. Eagles Black Friday NFL picks
The NFL Black Friday Game features a pair of 8-3 teams as the Eagles host the Bears. Philly has won each of the last six matchups and is a 7-point favorite in this contest. NFL expert Adam Silverstein, who is 40-25-2 (+1260) over his last 67 picks in Eagles games, is backing Philadelphia to cover, saying, "The Eagles will be fuming off the Cowboys loss and back at home where it has covered three of the last four. The offensive issues are a legitimate concern, but Chicago is not stout enough defensively to stop Jalen Hurts & Co., especially with the team at its peak motivation coming off the terrible Dallas loss." See Silverstein's full analysis here.
SportsLine's self-learning AI, which has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 NFL season, projects Bears WR Rome Odunze to go Under 3.5 receptions (+110). SportsLine AI forecasts Odunze to have 2.2 receptions in a prop pick rated 5 stars. Get more picks from SportsLine AI here.
















