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There are 12 games on the Sunday NFL schedule, and the latest bet365 bonus code CBSBET365 gives new users $200 in bonus bets after placing a first wager of $5 or more. The Bills and Chiefs will meet in a must-see AFC showdown, with the Chiefs trying to extend their three-game winning streak.

However, SportsLine's proven computer model is backing the Bills to cover the spread as 2-point home underdogs as one of its Sunday NFL best bets. It is also targeting the Saints (+14) to cover against the Rams and the Under (48) in Commanders vs. Seahawks on Sunday Night Football. Claim the latest bet365 bonus code here:

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The SportsLine Projection Model simulates every NFL game 10,000 times. The model enters Week 9 on a sizzling 45-28 run on top-rated picks dating back to 2024. The model enters the 2025-26 NBA season on a sizzling 160-118 roll on all top-rated NBA picks, returning nearly $4,000. Since its inception, it has also generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it enters Week 10 on a profitable 47-33 combined run on money-line and over/under college football picks since the beginning of 2024. Anybody following its NFL betting, college football betting or NBA betting picks at sportsbooks and on betting sites could have seen strong returns. Bet games at bet365 here:

Sunday's top NFL picks, best bets

  • Saints +14 vs. Rams
  • Bills +2 vs. Chiefs
  • Under 48 points in Commanders vs. Seahawks

Combining the model's three picks into a three-leg parlay at bet365 would result in a payout of +596 (risk $100 to win $595). Bet it at bet365 here:

Saints +14 vs. Rams

New Orleans has turned its offense over to rookie quarterback Tyler Shough, who is the franchise's highest-drafted quarterback since Archie Manning in 1971. Shough rushed for more than 250 yards twice during his seven-year college career, and his mobility will be a key factor behind a struggling offensive line. SportsLine's model has Shough racking up more than 200 total yards, helping the Saints cover the spread in 62% of simulations. Bet it at bet365 here:  

Bills +2 vs. Chiefs

Buffalo got off to an excellent start this season with a four-game winning streak, and it bounced back from an ensuing two-game losing skid with a 40-9 win at Carolina last week. Running back James Cook had 216 yards and two touchdowns, while quarterback Josh Allen accounted for three scores. Kansas City has lost two of its three road games this season, and the model has Buffalo covering the spread 58% of the time. Bet it at bet365 here:  

Under 48 in Commanders vs. Seahawks

Seattle has been one of the top defensive teams in the NFL this season, ranked seventh in points allowed per game (19.4). Commanders quarterback Jayden Daniels is returning from a hamstring injury and will be without trusted wide receiver Terry McLaurin (quad). The model barely has Washington scoring three touchdowns on Sunday night, as the Under hits 52% of the time. Bet it at bet365 here:  

Looking for more NFL picks?

You've seen the model's best bets for Sunday. Now, get against the spread, total and money-line picks for every NFL game here, all from the model that's simulated every game 10,000 times.