NFL longshot picks, 2025 Week 6 odds, player props: This parlay would return well over $44,000 on a $10 bet

The Week 6 NFL schedule features a compelling slate of matchups across the league, highlighted by several key games that could help shape the NFL playoff picture. The Denver Broncos (-7.5, 43.5), fresh off their 21-17 win over the defending Super Bowl champion Philadelphia Eagles, head to London to take on the New York Jets, the Pittsburgh Steelers (-4.5, 38.5) host the Cleveland Browns in an AFC North rivalry, and the Tampa Bay Buccaneers (-2.5, 43.5) host the San Francisco 49ers. The Sunday slate wraps up with the Detroit Lions taking on the Kansas City Chiefs (-2.5, 49.5). Lastly, 'Monday Night Football' features a double-header with Bills (-3.5, 48.5) vs. Falcons and Bears vs. Commanders (-4.5, 50.5).

Effectively building NFL parlay picks can pay off big in your NFL betting strategy. NFL parlays come with a much greater risk than straight bets, but they also carry the potential of a much bigger reward. Before making any Week 6 NFL picks and parlays, you need to see the Week 6 NFL longshot parlay from SportsLine's proven computer simulation model that pays out well over $44,000 on a $10 bet. 

You can bet this NFL parlay using the latest DraftKings promo code, which offers $200 in bonus bets if your first $5 bet wins:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 41-21 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now that the simulation model has had a chance to digest the Week 6 NFL odds, it's locked in its betting picks to form a 5-leg NFL parlay that could pay out well over $44,000 for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.

New users can also target the latest Underdog promo code, good for $100 in site credits when you play $5 with the promo code CBSSPORTS2  in select states.

Top Week 6 NFL parlay picks

For Week 6, one of the model's parlay picks is backing the Colts at the alternate line of -9.5 against the Cardinals, a bet that returns +160. The standard spread is Colts -5.5, but the model has spotted an opportunity to go much bigger here. 

The Colts are projected to win 70% of the time, and the model's winning margin is 10 points, leaving plenty of room to play alternate lines. The Colts have been one of the biggest surprises of the 2025 NFL season, and they own a perfect 3-0 record in games at Lucas Oil Stadium. The Cardinals, meanwhile, are coming off a disappointing collapse in their 22-21 loss to the Titans in Week 5. The loss was Arizona's third in a row.

With Daniel Jones now the starting quarterback and Anthony Richardson in a reserve role, the Colts are banking on stability and experience under center. Through the first five weeks of the 2025 season, Indianapolis has averaged over 24 points per game while ranking in the top half of the league in total offense and rushing yards behind a resurgent Jonathan Taylor. The defense, anchored by veterans like DeForest Buckner, has taken a step forward in 2025. See the rest of the picks in the Week 6 NFL parlay here.

New users can also check out the latest FanDuel promo code and get $300 in bonus bets instantly at FanDuel if your $5 bet wins. 

How to make NFL parlay picks for a payout of well over $44,000

The parlay also includes four additional picks from SportsLine's computer model, including a first touchdown scorer prop bet that returns +1100. You can only see the picks and the full parlay at SportsLine.

What are the top NFL picks for Week 6 that can be combined into a parlay that returns well over $44,000 on just a $10 bet? And what optimal first touchdown scorer bet returns +1100? Visit SportsLine now to see the top Week 6 NFL picks from SportsLine's proven model that can be combined for a parlay that pays well over $44,000, and find out.