Self-learning AI releases NFL picks, score predictions every Week 12 game

A 14-game slate is featured in NFL Week 12, including a number of matchups with playoff implications. Among the biggest is when the AFC South-leading Indianapolis Colts led by quarterback Daniel Jones face the nine-time defending AFC West champion Kansas City Chiefs and quarterback Patrick Mahomes, The Chiefs have struggled to a 5-5 mark this season, which makes this as close to a must-win situation as can be this far into the season for Kansas City. A key NFC North battle pits the 4-6 Minnesota Vikings against the 6-3-1 Green Bay Packers. The Chiefs are -3.5, while the Packers are favored by 6.5, making them two of the nine home favorites on Sunday and Monday.

A non-divisional matchup with heavy NFC playoff race implications will be played on Sunday Night Football when the Tampa Bay Buccaneers meet the Los Angeles Rams. Los Angeles has won eight of the past 10 meetings, with Tampa Bay pulling out a 16-13 win in the last meeting on Nov. 6, 2022. Sunday's largest spreads are Jets vs. Ravens (-13.5), Seahawks (-13) vs. Titans, Giants vs. Lions (-10.5) and Patriots (-7) vs. Bengals.

Before making any Week 12 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.

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Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season. 

For Week 12 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 14 games. You can only see the AI predictions for the Week 12 NFL schedule here.

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Top Week 12 NFL AI picks

After analyzing every game in Week 12, the AI says the Seahawks (-13) cover comfortably on the road against the Titans, who have lost five in a row. Quarterback Sam Darnold has played well in his first season in Seattle. In 10 games, he has completed 70.2% of his passes for 2,541 yards and 17 touchdowns with 10 interceptions and a 105 rating. In the Week 11 21-19 loss to the Rams, Darnold completed 29 of 44 passes for 279 yards. He was 21 of 24 passing for 330 yards and four touchdowns in a 38-14 win at Washington on Nov. 2.

Tennessee has struggled of late, losing six games by double digits. Rookie quarterback Cam Ward is still finding his footing for the Titans. In 10 starts, he has completed 58.4% of his passes for 1,954 yards and six touchdowns with six interceptions. SportsLine AI rates the Seahawks as an A+ spread pick and also predicts a 30-14 win on average. See its other Week 12 football predictions and football picks at SportsLine, and bet the Seahawks here:

How to make Week 12 NFL picks

In addition, the AI PickBot has generated well over 20 highly-coveted A+ picks for Week 12. You need to see the AI's NFL picks before making any Week 12 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 12 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.