emeka-egbuka-tampa-bay-buccaneers
Imagn Images

Money-line favorites in the NFL had a rough Week 5, going 7-7 straight-up. Given the uncertainty, hitting on exact NFL score predictions could result in a huge payday of around 100-1. Can the Ravens (+7) avoid a 1-5 start with a win over the Rams at home, even with Lamar Jackson out? And will Kansas City (-2.5) avenge a tough Monday loss with a victory over 4-1 Detroit on Sunday Night Football, in what could be a Super Bowl preview? 

What should one make of the Monday Night Football two-game slate of Bills vs. Falcons (+4.5) and Bears vs. Commanders (-4.5), with the latter being the teams' first meeting since Washington's Hail Mary victory a year ago? Before making any Week 6 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

New users can also target the DraftKings promo code, which offers $200 in bonus bets if your bet wins:

A SportsLine expert and host, Cohen is evaluating the entire Week 6 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight-up NFL betting picks (69%) and was profitable for bettors. He's 50-27-1 (65%) on straight-up picks so far this season. Anyone who followed Cohen's NFL predictions has been profitable at their favorite sports betting sites and betting apps. You can only see Cohen's Week 6 NFL exact score predictions at SportsLine.

New users can also target the latest Underdog promo code, good for $100 in site credits when you play $5 with the promo code CBSSPORTS2 in select states.

Top Week 6 NFL picks

After diving into all 15 games on the NFL Week 6 schedule, Cohen likes the Buccaneers (-3.5, 46.5) to win and cover at home against the 49ers at 4:25 p.m. ET on Sunday, even as the Bucs deal with a lengthy injury list that includes running back Bucky Irving (foot/shoulder), receiver Chris Godwin (fibula) and receiver Mike Evans (hamstring) all out. 

"You can parlay a Baker Mayfield MVP-Emeka Egbuka Rookie of the Year ticket at more than 20-1 odds. The way both are playing, I don't hate it. The Buccaneers are in a class by themselves in the NFC South and will be hosting a playoff game come January. I can make an argument for a 13-4 season if all goes well for Tampa Bay. And many props to San Francisco for being 4-1 and winning last Thursday in LA, but this isn't a good spot for them with still plenty of injury concerns to navigate on offense including Brock Purdy (toe) being out and backup Mac Jones expected to start despite not practicing this week (knee, oblique). Buccaneers 28, 49ers 21." See his other Week 6 football score predictions at SportsLine.

How to make Week 6 NFL score predictions

In addition, Cohen is picking one team to blow out their opponents by three touchdowns. You can see who it is at SportsLine, and use promo code CHAMPIONSHIP to get your first month at SportsLine for just $1.

Who wins every Week 6 NFL game, and underdogs pull upset victories? Visit SportsLine now to get Eric Cohen's NFL Week 6 score predictions, all from the NFL expert who has nailed 65% of his NFL straight-up picks this season, and find out.