NFL picks this week, odds, lines, bets: Week 6, 2025 expert predictions against the spread, parlay, prop bets

The Week 6 NFL schedule has a bit of everything with the biggest NFL spread of the season, a potential Super Bowl preview on Sunday night and a two-game slate on Monday. Packers vs. Browns has Green Bay as 14.5-point favorites, per the Week 6 NFL odds, making the Pack the biggest favorite, thus far, of the 2025 NFL season. Meanwhile, SNF will have one of the slimmest NFL lines with Chiefs vs. Lions (+2.5), which is a matchup many would like to see again come February. Then on MNF, there are identical 4.5-point spreads with Buffalo favored versus Atlanta, as well as Washington favorites against Chicago.

Those are just a handful of the 15 games you can make Week 6 NFL bets, prop predictions or create an NFL parlay on. Having quality NFL betting advice is almost a must with so much information and data to keep track of, especially when injuries to star players cause line movements. NFL expert predictions would go a long way in making your football bets winning ones. Before locking in any Week 6 NFL picks or NFL prop bets, be sure to check out the Week 6 NFL best bets and predictions from SportsLine's red-hot Vegas experts.

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SportsLine has more than 40 hand-picked Vegas experts who excel in multiple spots. The NFL, however, is a strength for the site as SportsLine currently has five total experts who are on NFL runs that have returned $700 or more for $100 players and one who has returned more than $1,400. Anybody following could have seen huge returns. 

Now, with the Week 6 NFL schedule quickly approaching, SportsLine's top NFL betting experts are already locking in their picks. Go to SportsLine to see them all now.

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Top Week 6 expert NFL prop picks from Doug Kralstein 

Better known as 'Prop Bet Guy,' Kralstein specializes in NFL props, and he enters Week 5 on a 32-20 run on NFL player props that has returned nearly $900 for $100 bettors. One of his top prop picks this week is going Over 4.5 receptions (-128) for Xavier Worthy of the Chiefs against the Lions.

"This is a bit of an eye-opening line for Xavier Worthy, who has at least five catches in 10 straight full games dating back to last season," he said. "He'll face a Lions secondary that's down their top three cornerbacks, and both safeties are also banged up. The Chiefs should have to air it out in this matchup as is, with their run game struggling, and the Lions ranked fourth in run defense DVOA (per FTN)." You can see all of Kralstein's NFL picks here.

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Top Week 6 NFL expert picks from Thomas Casale

A frequent guest on national radio and TV shows, Casale has been betting -- and winning -- for more than 30 years. He sets his own lines for each game, then looks at the metrics to see where he can find an edge in the number and is profitable across a number of pro and college sports. He is picking Seattle (-1.5) to cover at Jacksonville on Sunday.

"I like this spot for Seattle. Jacksonville is coming off the emotional win over the Chiefs and while Trevor Lawrence played well on the final drive, it overshadowed an otherwise inconsistent performance. I think it's a good matchup for a Seahawks team that already has two road wins this season." See all of Casale's NFL picks at SportsLine. 

Top Week 6 NFL expert picks from Jeff Hochman

A handicapper who emerged on the betting scene in the 1990s, Hochman is is 83-66-3 (plus $1,217 for $100 players) over the past four NFL seasons. He's also on a 7-4 run (+235) over his last 11 NFL ATS picks and likes the Titans (+3.5) to cover versus the Raiders.

"The Raiders' offense is struggling without tight end Brock Bowers, who won't return until at least Week 7. Rookie RB Ashton Jenty is ranked 12th in snap percentage but tends to wear down late in games. The Titans should be able to move the ball against the Raiders' defense, which has a low pressure rate of 32.0% when blitzing and only 21.2% on non-blitz dropbacks... Geno Smith is 11-20-2 ATS as a favorite. I like the road dog." See all of Hochman's NFL picks at SportsLine.

How to make Week 6 NFL against the spread picks

SportsLine's team of experts also includes R.J. White, who is the site's all-time leading NFL expert and is this season's top expert as well, returning more than $2,400 on his past 92 picks. He has eight more picks on the board, including in a game where he sees the line as being four points off. You can find out who his NFL picks are this week here.

If you are looking for NFL picks, NFL props, or NFL best bets for Week 6, SportsLine has you covered with its proven team of experts. Visit SportsLine now to see who which teams you should back in Week 6, all from a staff that includes five experts who are on NFL runs that have returned $700 or more for $100 players.