Self-learning AI reveals NFL against the spread, over/under and money-line picks for every Week 7, 2025 game

The AFC West race heats up in Week 7 with several key battles, including a matchup between longtime bitter rivals when the Kansas City Chiefs take on the Las Vegas Raiders at Kansas City. The Chiefs (3-3), who are third in the division, are just one game out of first place. The Chiefs have won the division in each of the past nine seasons. Other AFC West teams in action include the Denver Broncos (4-2), who play the New York Giants (2-4) at Denver, and the Los Angeles Chargers (4-2), who play the AFC South-leading Indianapolis Colts (5-1) in Los Angeles. The Chiefs are 12-point favorites over the Raiders (2-4), the Broncos are 7-point favorites over the Giants and the Chargers are 1.5-point favorites over the Colts.  

How should you handle those NFL games and optimize what to bet on NFL in Week 7? Before making any Week 7 NFL picks or Week 7 NFL score predictions, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.

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Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season. 

For Week 7 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting picks for all 15 games. You can only see the AI predictions for the Week 7 NFL schedule here.

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Top Week 7 NFL AI picks

After analyzing every game in Week 7, the AI says the Chiefs cover comfortably against the Raiders. Kansas City quarterback Patrick Mahomes has been dominant completing 64.8% of his passes for 1,514 yards and 11 touchdowns with just two interceptions. In the 30-17 win over the Detroit Lions, Mahomes completed 22 of 30 passes (73.3%) for 257 yards and three touchdowns. He completed 29 of 41 passes (70.7%) for 318 yards and one touchdown with one interception in a 31-28 loss to the Jacksonville Jaguars on Oct. 6.

Mahomes is well on his way to a Hall of Fame career. He is in his ninth season with Kansas City after being drafted in the first round of the 2017 NFL Draft. In 118 career games, he has completed 66.5% of his passes for 33,866 yards and 256 touchdowns with 76 interceptions for a rating of 101.9. He has led Kansas City to five Super Bowls, winning three championships.

AI PickBot rates a Chiefs cover as an B pick and also predicts a 31-17 win on average. See its other Week 7 football predictions and football picks at SportsLine.

How to make Week 7 NFL picks

In addition, the AI PickBot has generated well over 30 highly-coveted A+ picks for Week 7. You need to see the AI's NFL picks before making any Week 7 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 7 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.