josh-allen-buffalo-bills
Imagn Images

A week after seizing control of the AFC South with a shootout victory over the Seattle Seahawks 38-35, the Tampa Bay Buccaneers will face another stiff test when they battle the NFC West-leading San Francisco 49ers (+3.5). San Francisco is coming off a 26-23 victory over the Los Angeles Rams on Thursday Night Football. The Buccaneers are 2-1 in the conference, while the 49ers are 4-0 against NFC foes. There are a number of intriguing matchups on the Week 6 NFL schedule, including Rams vs. Ravens (+7), with Lamar Jackson ruled out, Seahawks vs. Jaguars (-1.5), Lions vs. Chiefs (-2.5) on Sunday Night Football and Bears vs. Commanders (-4.5) on Monday Night Football. 

Which other teams have value to include in Week 6 NFL parlay bets, and which side of the NFL odds should you target? Before locking in any Week 6 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

New users can also target the DraftKings promo code, which offers $200 in bonus bets if your bet wins:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 41-21 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has scoured the Week 6 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 6 NFL picks at SportsLine.

New users can also check out the latest FanDuel promo code and get $300 in bonus bets instantly at FanDuel if your $5 bet wins:

Top Week 6 NFL picks

After simulating every game 10,000 times, the model is high on the Buffalo Bills (-4.5, 50) to cover against the Atlanta Falcons on Monday Night Football. The Bills are stinging from a 23-20 loss to the New England Patriots on Sunday Night Football. Buffalo, which is 8-2 over its last 10 primetime games, will look to rebound against a 2-2 Falcons team coming off a bye. Atlanta defeated Washington 34-27 in Week 4.

The Bills are led by quarterback Josh Allen, who is having a solid season so far. In the loss to the Patriots, he completed 22 of 31 passes (71%) for 253 yards and two touchdowns with one interception. He has thrown for over 1,200 yards this season with nine touchdowns and two picks. Running back James Cook leads the rushing attack, carrying 90 times for 450 yards (5.0 average) and five touchdowns. The model has Buffalo outright winning nearly 80% of the time and covering in 70% of simulations. See which other NFL parlay picks to make here, and bet the Bills to cover here:

How to make Week 6 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will not only cover, but win outright. You can only see the model's Week 6 NFL best bets and NFL parlay at SportsLine.

What are the model's top Week 6 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from a model on a 41-21 run on top-rated picks, and find out.