NFL longshot picks, Week 1 2025 odds, props: This parlay could return over $4,000 on a $10 bet

The Week 1 NFL schedule is approaching and the league has again spread it out over four different days. The latest Week 1 NFL odds list the Eagles at -7 against the Cowboys in the 2025 NFL Kickoff Game on Thursday, Sept. 4. The Chiefs are -3 against the Chargers in Brazil on Friday. Thirteen other games are set for that Sunday, with Bears (-1.5) vs. Vikings concluding the slate on Monday Night Football. 

Effectively building NFL parlay picks can pay off big in your NFL betting strategy. NFL parlays come with a much greater risk than straight bets, but they also carry the potential of a much bigger reward. Before making any Week 1 NFL picks and parlays, you need to see the Week 1 NFL longshot parlay from SportsLine's proven computer simulation model that pays out well over $4,000 on a $10 bet. You can bet this NFL parlay using the latest DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks its since inception. The model went 31-15 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now that the simulation model has had a chance to digest the Week 1 NFL odds, it's locked in its betting picks to form a 5-leg NFL parlay that could pay out over $4,000 for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.

Top Week 1 NFL parlay picks

For Week 1, one of the model's parlay picks is backing the Buccaneers at the alternate line of -7.5 against the Falcons, a bet that returns +255. The standard spread is Bucs -1.5, but the model has spotted an opportunity to go much bigger here. 

The Bucs are projected to win nearly 70% of the time and the model's winning margin is 8 points, leaving plenty of room to play alternate lines. Tampa Bay returns its explosive offensive core, and even drafted Emeka Egbuka to bolster a strong group of receivers for quarterback Baker Mayfield.

Tampa Bay was also elite defensively late in the 2024 season, allowing just 17 points per game in the final seven games of the season. Atlanta has more question marks overall, and SportsLine's model likes Tampa Bay's chances of going on the road and grabbing a big season-opening win. See the rest of the picks in the Week 1 NFL parlay here, and new users can check out the latest bet365 bonus code to get $200 in bonus bets after placing a $5 bet:

How to make NFL parlay picks for a payout of over $4k

The parlay also includes four additional picks from SportsLine's computer model, including an anytime touchdown scorer bet that returns +500. You can only see the picks and the full parlay at SportsLine.

What are the top NFL picks for Week 1 that can be combined into a parlay that returns over $4,000 on just a $10 bet? And what optimal touchdown scorer bet returns +500? Visit SportsLine now to see the top Week 1 NFL picks from SportsLine's proven simulation model that can be combined for a parlay that pays well over $4,000, and find out.