NFL DFS, Sunday Night Football: Top FanDuel, DraftKings daily Fantasy football picks for Chiefs vs. Lions
DFS millionaire Mike McClure shares his top daily fantasy football picks and lineup advice for Detroit vs. Kansas City on 'Sunday Night Football'

NFL DFS players have a fascinating matchup on 'Sunday Night Football' as the Chiefs and Lions meet in Kansas City at 8:20 p.m. ET during the Week 6 schedule. With an over/under of 51.5 points, it is projected to be the highest-scoring game of the week, and players like Patrick Mahomes, Travis Kelce, Jared Goff, Jahmyr Gibbs and Amon-Ra St. Brown make great potential building blocks for NFL DFS lineups.
Which NFL DFS picks for 'Sunday Night Football' have the most value, and who are some of the NFL DFS sleepers you can target in this potential high-scoring matchup? Before locking in any NFL DFS picks on sites like DraftKings and FanDuel, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure.
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McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up.
Now, McClure has turned his attention to Chiefs vs. Lions, and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.
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Top NFL DFS picks for Lion vs. Chiefs
One of McClure's top NFL DFS picks for 'Sunday Night Football' is Kansas City quarterback Patrick Mahomes, who has an over/under of 262.5 passing yards. The former Texas Tech standout remains one of the premier fantasy quarterbacks in the NFL today. Mahomes has thrown for at least 26 touchdowns in each of his seven full seasons as Kansas City's starter.
In 2025, Mahomes has gotten off to another solid start. He enters Week 6 with 1,257 yards, eight touchdowns, and two interceptions. The three-time NFL MVP has been more active with his legs in 2025, rushing for 190 yards and three touchdowns -- both team highs -- through five games. See who else to roster here.
Part of McClure's optimal NFL DFS strategy also includes rostering Lions running back Jahmyr Gibbs. The former first-round pick is known for his speed, agility and ability to impact both the ground game and passing attack. In 2024, Gibbs took a major leap forward, rushing 250 times for 1,412 yards (5.6 yards per carry) while scoring 16 rushing touchdowns, and adding 52 receptions for 517 yards and four receiving touchdowns -- combining for a franchise-record 20 total touchdowns.
Through the early part of the 2025 season, Gibbs has logged 70 carries for 325 rushing yards (4.6 yards per carry) and four rushing touchdowns, along with 22 receptions for 112 yards and one receiving touchdown. While his per-game numbers are down slightly, his versatility continues to be a key weapon in Detroit's offensive scheme. Gibbs' ability to create big plays both as a runner and receiver keeps him at the center of the Lions' offensive attack. See who else to roster here.
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How to set NFL DFS lineups for 'Sunday Night Football'
McClure is targeting another undervalued player who could explode for huge numbers on Sunday night. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine.
So who is Mike McClure including in his optimal NFL DFS lineups for Sunday night, and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.