Monday Night Football NFL player props, Week 6: Self-learning AI says James Cook goes Over 16.5 carries
NFL player prop picks and SGP bets for Bills vs. Falcons and Bears vs. Commanders on 'Monday Night Football'
The Week 6 NFL schedule wraps up with a 'Monday Night Football' doubleheader between the Buffalo Bills and Atlanta Falcons at 7:15 p.m. ET, and the Chicago Bears and Washington Commanders at 8:15 p.m. ET. Both games have an Over/Under of 49.5, suggesting there could be plenty of offense on Monday night. Both games will feature talented quarterbacks, and plenty of explosive playmakers all over the field. The Bills are 4.5-point road favorites in their game against the Falcons, while the Commanders are 4.5-point favorites at home against the Bears.
Should you target Josh Allen or Jayden Daniels when making Week 6 MNF player prop bets, or should you look at props for other star players like James Cooks Bijan Robinson, Caleb Williams or DJ Moore? Before making any 'Monday Night Football' NFL prop picks, you need to see the MNF prop predictions powered by SportsLine's Machine Learning Model AI.
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Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each player prop.
For Bills vs. Falcons and Bears vs. Commanders NFL betting on 'Monday Night Football,' the Machine Learning Model has evaluated the NFL player prop odds and provided NFL prop picks. You can only see the Machine Learning Model player prop predictions for here.
Top NFL player prop bets for 'Monday Night Football'
After analyzing the Bills vs. Falcons and Bears vs. Commanders props and examining the dozens of NFL player prop markets, the SportsLine's Machine Learning Model says James Cook goes Over 16.5 carries (+101).
Cook broke out in 2024, carrying the ball 207 times for 1,009 rushing yards (4.9 YPC average) and scoring 16 rushing touchdowns, while also adding 32 catches for 258 receiving yards and 2 touchdowns. In 2025, through five games, he's already recorded 90 carries for 450 yards (5.0 YPC) and five rushing touchdowns, along with 12 receptions for 89 yards. His efficiency remains impressive, and he's continued to be a key scoring threat for Buffalo.
SportsLine's model is projecting 19.9 carries for Cook as he's in a spot where the Bills might rely heavily on their rushing attack. The two-time Pro Bowl selection is averaging 18 carries per game in 2025, and the model rates this as a strong 5-star play. See more NFL props here.
How to make NFL player prop bets for Bills vs. Falcons and Commanders vs. Bears
In addition, the SportsLine Machine Learning Model has revealed several other strong picks, including four 4.5-star picks featuring some of the biggest names in action on Monday. You can only see the picks here.
Which Falcons vs. Bills and Bears vs. Commanders prop bets should you target for 'Monday Night Football?' Visit SportsLine now to see the top props, all from the SportsLine Machine Learning Model.
