How to bet on NFL Week 1: Where to bet, betting sites, promos, Cowboys vs. Eagles, Chiefs vs. Chargers betting
Here's how to bet on the Week 1 NFL schedule, including the Seattle Seahawks vs. San Francisco 49ers and Atlanta Falcons vs. Tampa Bay Buccaneers
Week 1 of the NFL schedule begins with the 2025 NFL Kickoff Game between the Eagles and Cowboys on Thursday, September 4 and continues with Chiefs vs. Chargers on Friday from Brazil. A full Sunday schedule is capped off by Bills vs. Ravens on Sunday Night Football and Vikings vs. Bears wraps up the week on Monday Night Football. The Bills are 1.5-point favorites in the latest NFL odds, while the over/under is 52.5 points. Bettors who are wondering how to bet on NFL and where to bet on NFL football will also be interested in Buccaneers vs. Falcons and 49ers vs. Seahawks, four teams with a chance of competing for the postseason.
Bettors looking for sportsbook promos and betting sites for Week 1 of the 2025 NFL season can read more below, along with picks for some of the biggest games.
Sportsbook offers
Here are the top sportsbook promos for new users ahead of the 2025 Week 1 NFL schedule.
The DraftKings promo code, bet365 bonus code and FanDuel promo code all offer bonus bets after new users place a wager of $5 or more. DraftKings is offering $300 in bonus bets in addition to more than $200 off NFL Sunday Ticket for the upcoming season. bet365 is offering new users either $200 in bonus bets with the placement of a $5+ bet, or up to a $1,000 first bet safety net. FanDuel's latest promo code offers new users $300 in bonus bets if their first bet of at least $5 wins.
Both the BetMGM bonus code and Fanatics Sportsbook promo code provide bonus bets, but only if your first bet loses. New users at Fanatics have the ability to get $100 No Sweat Bets in FanCash on every football Game Day from Aug. 23 to October. Users in New York are limited to $25 in No Sweat Bets in FanCash. Meanwhile, the BetMGM bonus code CBSSPORTS awards new users up to $1,500 back in bonus bets if their first bet loses. BetMGM users in New Jersey, West Virginia, Pennsylvania or Michigan can get a different promotion and receive $150 in bonus bets if you win your first bet of $10 or more.
The Caesars Sportsbook promo code is completely different than the others, offering profit boosts instead of bonus bets. After placing a wager of $1 or more, you receive 20 100% profit boost tokens with the code CBS20X.
Betting on Week 1 of the 2025 NFL season
SportsLine's computer model simulates every NFL game 10,000 times. Since its inception, it has generated a betting profit of well over $7,000 for $100 players on top-rated NFL picks. The model went 31-15 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Seahawks ML (+114) vs. 49ers
The Seahawks open the 2025 NFL season in Seattle in an NFC West rivalry matchup against a San Francisco team that, although it has Christian McCaffrey back, still wouldn't be considered a healthy bunch. Wide receiver Brandon Aiyuk remains out with a knee injury, and fellow receiver Jauan Jennings hasn't been on the field all training camp amid a calf injury and contract disputes. Sam Darnold makes his Seattle debut after signing a three-year, $100.5 million contract. He's been doubted before, and in return, Darnold threw for 4,319 yards and led the Vikings to a 13-4 record last season. The SportsLine model projects Seattle to win in almost 60% of simulations, showing strong value at plus-money odds.
Buccaneers (-1.5) vs. Falcons
Tampa Bay has won four straight NFC South championships as arguably the most underrated team in the NFL despite consistently winning its division. Tampa Bay lost offensive coordinator Liam Coen to the Jaguars, but Baker Mayfield and the Buccaneers have been in this situation before, as each of their last two offensive coordinators left to become head coaches. Mayfield and Tampa Bay have shown no issues winning under different playcallers, and the model expects that to continue in Week 1. There's excitement in Atlanta around quarterback Michael Penix Jr, who led the Falcons to average 32 points per game over his three starts late in the season, but the Falcons went 1-2 with their only win against the 3-14 Giants over that span. The No. 8 overall pick in the 2024 NFL Draft is still a young, inexperienced quarterback making his first Week 1 NFL start with an entire offseason for Tampa Bay to game plan for him. The model projects Tampa Bay to cover the spread in well over 60% of simulations.
Commanders (-6) vs. Giants
The Commanders and Terry McLaurin agreed to a new contract at the end of the preseason, so Washington will have its full complement of playmakers on the field in Week 1. That's a significant relief as Jayden Daniels excelled with McLaurin as his WR1, winning Offensive Rookie of the Year and leading the Commanders to a 12-5 season and the NFC Championship Game. Washington went 12-7-1 against the spread, including the playoffs, last season. The Commanders went 7-2 ATS at home, including 6-2 as a home favorite, and the Giants went 2-5 as a road underdog last season. The model projects the Commanders to cover the spread in over 60% of simulations.
Responsible gaming
It's important for bettors to understand responsible gaming and not fall into dangerous habits such as chasing losses. Sportsbooks offer tools such as time and wager limits to help out their users in this regard. Bettors can also use national resources like The National Council on Problem Gaming, Gamblers Anonymous and 1-800-GAMBLER.
