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The New York Giants and Detroit Lions will match up in Week 12 of the 2025 NFL season with both franchises trending in opposite directions. The Giants are operating under an interim head coach but hope to get rookie sensation Jaxson Dart back for this contest, while the Lions try to bounce back from a loss to the Eagles on Sunday Night Football in Week 11 to prove they are still contenders. The Giants are 2-9 entering this game while the Lions are 6-4.

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Where to bet on Giants vs. Lions

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Where to watch Giants vs. Lions on Sunday

When: Sunday, Nov. 23
Time: 1 p.m. ET
TV: FOX
Follow along: CBS Sports App

Giants vs. Lions betting preview

Odds: Lions -10.5, over/under 50

While Detroit has struggled in outdoor environments, the Lions are a juggernaut at home on offense. They should be able to rebound from a poor showing in Week 11 against the Giants, who are tied for 29th in points allowed per game at 27.3. Detroit is averaging 29.2 points per game, which is tied for fourth-best in the NFL.

Click here to bet Giants vs. Lions at FanDuel Sportsbook, where new users get $150 in bonus bets if their first bet of at least $5 wins:

Giants vs. Lions SGP

  • Lions -10.5 (-110)
  • Over 50.5 (-108)
  • Amon-Ra St. Brown anytime touchdown scorer (-135)

Final odds: +415 at DraftKings (wager $100 to win $415)

Model's Giants vs. Lions score prediction, picks

The SportsLine Projection Model has the Lions covering the 10.5-point spread in 53% of simulations, but it does see value in backing the Giants on the money line as +441 underdogs. New York wins in 22% of simulations to bring value at those odds. With Detroit's propensity to run up the score on teams at home, the model likes the Over on 50, which hits in 55% of simulations.

Giants vs. Lions score prediction: Lions 32, Giants 21

Want more Week 12 NFL picks?

You've seen the model's best bets for New York Giants vs. Detroit Lions. Now, get against the spread, total and money-line picks for every Week 12 NFL game here, all from the model that's simulated every game 10,000 times.