Cowboys vs. Eagles prediction, odds, time: 2025 NFL Kickoff Game picks, best bets from proven computer model

The defending Super Bowl champion Philadelphia Eagles will open their campaign against the Dallas Cowboys in the 2025 NFL Kickoff Game on Thursday, Sept. 4. Philadelphia went 14-3 in the regular season and capped its playoff run with a 40-22 win over Kansas City in the Super Bowl. Dallas missed the playoffs last year with a 7-10 record, as quarterback Dak Prescott played just eight games before suffering a season-ending hamstring injury. This is the first Week 1 meeting between these NFC East rivals since 2000. 

Kickoff from Lincoln Financial Field in Philadelphia is set for 8:20 p.m. ET on Thursday, Sept. 4. The Eagles favored by 7 points in the latest Eagles vs. Cowboys odds at FanDuel Sportsbook, while the over/under for total points scored is 46. Before locking in any Cowboys vs. Eagles picks, be sure to see what the SportsLine projection model has to say. New users can also target the DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks its since inception. The model went 31-15 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.  

Now, the model has zoned in on Eagles vs. Cowboys. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Cowboys vs. Eagles:

Why the Eagles can cover

Philadelphia swept the 2024 season series between these teams with two blowout wins, outscoring Dallas by a combined score of 75-13. Eagles running back Saquon Barkley led the NFL in rushing attempts, rushing yards and rushing yards per game last season, finishing with 2,504 yards by the time the playoffs ended. He rushed for at least 118 yards in three playoff games, and he is facing a Dallas defense that was fourth-worst in the NFL in rushing yards allowed per game last season 

Quarterback Jalen Hurts tallied 630 rushing yards during the 2024 regular season, averaging 42 yards per game. He added 194 rushing yards in the playoffs (48.5 ypg), and he had 56 rushing yards on seven carries in his lone meeting with Dallas last season. The Eagles are riding an 11-game home winning streak and have covered the spread in six of their last seven NFC East games. See which team to back at SportsLine. 

Why the Cowboys can cover

Dallas is happy to have Prescott back on the field, as its offense struggled without him last season. The Cowboys acquired wide receiver George Pickens, who led the NFL in yards per reception (18.1) in 2023 and caught 12 passes of 30-plus air yards last season. He gives Prescott another elite target alongside star wideout CeeDee Lamb. 

The Eagles lost cornerback Darius Slay and will have either rookie Andrew Mukuba or inexperienced Sydney Brown on the field. Dallas covered the spread in five of its final seven games last season, and it has won 14 of its last 20 divisional games outright. The Cowboys are motivated to avenge their blowout losses to the Eagles from 2024, while the defending champions could be dealing with a Super Bowl hangover. See which team to back at SportsLine, and new users can also check out the latest bet365 bonus code to get $200 in bonus bets after placing a $5 bet:

How to make Cowboys vs. Eagles picks

For Thursday's NFL Kickoff Game, the model is leaning Over the total, and also indicates that one side of the spread is hitting in well over 50% of simulations. See what it is at SportsLine.

Who covers in Eagles vs. Cowboys and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Cowboys vs. Eagles spread you need to jump, all from the model that went 31-15 on top-rated picks in 2024, and find out.