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Wednesday's NBA schedule is packed with 12 matchups, including a Western Conference showdown featuring the Los Angeles Clippers hosting the Denver Nuggets at 10:30 p.m. ET. Denver is favored by two points on the road, according to the latest NBA odds at DraftKings Sportsbook, and the over/under is 226.5 points. Elsewhere on Wednesday's NBA schedule, the Detroit Pistons (-2.5) take on the Chicago Bulls at 7 p.m. ET, and the Miami Heat (-5.5) host the Cleveland Cavaliers at 7:30 p.m. ET. Three NBA picks involving the Clippers, Bulls and Cavaliers are part of an NBA parlay at DraftKings Sportsbook that pays out nearly 6-1.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 4 of the 2025-26 NBA season on a sizzling 26-13 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Three NBA betting picks for Wednesday, Nov. 12 (odds subject to change): 

  • Nuggets vs. Clippers: Over 226.5 points
  • Bulls (+2.5) vs. Pistons
  • Cavaliers (+5.5) vs. Heat

Combining the model's three picks into an NBA parlay at DraftKings would result in a payout of +581 (risk $100 to win $581).

Nuggets vs. Clippers: Over 226.5 points (-110, DraftKings)

The Nuggets feature one of the most explosive offenses in the NBA, and while Los Angeles has struggled early in the season, the Clippers still feature several explosive playmakers capable of stuffing the stat sheet. Clippers guard James Harden recorded a triple-double in his last start, and he's knocked down at least five 3-pointers in three of his last four games. SportsLine's model is expecting the Nuggets to secure a 118-115 victory on Wednesday, helping the Over hit in 60% of simulations. 

Bulls (+2.5) vs. Pistons (-115, DraftKings)

The Bulls have dominated this series over the years, winning 15 of the last 20 meetings against Detroit. Chicago enters Wednesday's tilt 8-2 against the spread in its last 10 games, and Detroit has lost 10 of its past 12 meetings against Chicago at home. SportsLine's model is calling for the Bulls to record a 116-115 win on Wednesday, as Chicago covers the spread in 67% of simulations. 

Cavaliers (+5.5) vs. Heat (-110, DraftKings)

The Cavs are just 3-10 against the spread in their last 13 games, but Cleveland has had success against Miami in recent years. The Cavaliers are 6-1 in their previous seven games against Miami. These two teams played on Monday, with Miami recording a 140-138 victory on its home floor. SportsLine's model is backing Miami to record another close win on Wednesday, but Cleveland covers the spread 58% of the time.