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There are 11 more games on the Wednesday NBA schedule, and the action is anchored by a couple national broadcasts between potential contenders. The latest NBA odds for Wednesday show the Knicks as 5.5-point favorites against the Timberwolves in a 7:30 p.m. ET tip. The Lakers, meanwhile, are -2.5 against the Timberwolves at 10 p.m. ET.

Other NBA lines of note for Wednesday include Nuggets (-8.5) vs. Heat, Cavaliers (-9.5) vs. 76ers and Kings (-3) vs. Warriors. What are the best NBA bets on the board? Before locking in any NBA picks, you'll want to see the NBA predictions and betting advice from SportsLine's proven computer model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 3 of the 2025-26 NBA season on a sizzling 26-13 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has scoured the latest NBA odds and locked in three confident NBA best bets. If you successfully parlay its picks, you'd be looking at a payout of more than +700. You can only see the model's NBA picks at SportsLine.

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Top NBA picks for Wednesday, Nov. 5

After simulating every game 10,000 times, the model is backing the Nets (+6.5) to cover at Indiana in one of the 7 p.m. ET tips. The Pacers have just one win this season as Indiana deals with a massive injury list. Eight players have been ruled out for this one with a mixture of short-term and long-term injuries including Tyrese Haliburton (Achilles), Bennedict Mathurin (toe) and T.J. McConnell (hamstring).

Brooklyn is winless this season, but the model can't justify laying 6.5 points with an Indiana team that is so decimated. Brooklyn gets 26 points from Cam Thomas and nearly 20 from Michael Porter Jr. in the simulations as the Nets keep it within a point and cover more than 60% of the time. See which other NBA parlay picks to make here.

How to make NBA predictions for Wednesday, November 5

The model also has locked in two other picks, including backing one underdog to win outright and bring a plus-money return on the money line. You can only see the model's NBA parlay at SportsLine.

What are the model's top NBA parlay picks for Wednesdasy, and which best bets should you target for a chance at a payout of more than +700? Visit SportsLine now to see NBA best bets from a model that's returned more than $10,000 on top-rated picks, and find out.