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Eastern Conference teams who are off to strong starts meet on Friday when the New York Knicks host the Miami Heat. New York is 7-4 and sits tied with the 76ers for second in the conference. The Heat, meanwhile, are 7-5 as they look to bounce back from a 37-45 campaign last season. Bam Adebayo (toe) and Tyler Herro (ankle) are among the players out for Miami. Jalen Brunson (ankle) has been ruled out for New York.

Tipoff is set for 7 p.m. ET at Madison Square Garden. New York is a 5.5-point home favorite in the latest Knicks vs. Heat odds, while the over/under is 238.5. Before making an Heat vs. Knicks picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 4 of the 2025-26 NBA season on a sizzling 26-13 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Heat vs. Knicks 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Knicks vs. Heat:

Knicks vs. Heat spread:    

Knicks -5.5

Knicks vs. Heat over/under:    

238.5 points

Knicks vs. Heat money line:    

Knicks -231, Heat +190

Knicks vs. Heat picks:    

See picks at SportsLine

Knicks vs. Heat streaming:

Amazon Prime 

How to make Knicks vs. Heat picks

SportsLine's model has simulated Heat vs. Knicks 10,000 times and is going Under 238.5 combined points. Both teams are missing some key scorers, with Brunson's absence particularly looming large from a scoring standpoint. Brunson ranks ninth in the NBA with 28 points per game.

SportsLine's model projects that Karl-Anthony Towns and Mikal Bridges pick up some that scoring slack, but no player from either team reaches 25 points in the simulations. The model projects 235 combined points as the Under hits in well over 50% of simulations.

The model also says one side of the spread hits more than 60% of the time. You can head to SportsLine to see the model's NBA picks

So who wins Knicks vs. Heat, and which side of the spread hits more than 60% of the time? Visit SportsLine now to see which side of the spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.