Celtics vs. Pistons odds, prediction, line, time: 2025 NBA Cup picks for November 26 from proven model

Group play in the 2025 NBA Cup continues on Wednesday, and the first tip of the day is the Boston Celtics (9-8) vs. the Detroit Pistons (15-2). The Pistons, who are on a 13-game winning streak overall, are 2-0 in group play, while Boston is 1-2. Boston is eliminated with a loss in this game. The Celtics would also be knocked out by an Atlanta win on Friday or both the Knicks and Heat winning on Wednesday. 

Tipoff from TD Garden is set for 5 p.m. ET. Detroit is a 2.5-point favorite in the latest Pistons vs. Celtics odds, while the over/under is 230.5. Before making any Celtics vs. Pistons picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 6 of the 2025-26 NBA season on a sizzling 28-13 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Celtics vs. Pistons 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Piston vs. Celtics:

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How to make Celtics vs. Pistons picks

SportsLine's model has simulated Celtics vs. Pistons 10,000 times and is leaning Over the total, projecting 237 combined points. 

Boston is coming off a game that went well over the total against Orlando last time out, while the Pistons have seen their last four games hit the Over. The model projects that the teams combine for 237 points as the Over hits in nearly 60% of simulations.

The model also says one side of the spread hits more than 50% of the time. You can head to SportsLine to see that pick. 

So who wins Pistons vs. Celtics, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.