Celtics vs. 76ers odds, prediction, line, time: 2025 NBA picks for October 31 from proven model

The Philadelphia 76ers look to stay unbeaten on the year when they battle the Boston Celtics in a 2025 NBA Cup matchup on Friday night. Philadelphia is coming off a 139-134 overtime win over the Washington Wizards on Tuesday, while Boston downed the Cleveland Cavaliers 125-105 on Wednesday. The Celtics (2-3), who have won two in a row, are 1-2 on the road this season. The 76ers (4-0), who are first in the Atlantic Division, are 2-0 on their home court. Paul George (knee) and Jared McCain (thumb) are out for the Sixers. 

Tipoff from Xfinity Mobile Arena in Philadelphia is set for 7 p.m. ET. Boston is a 1-point favorite in the latest Celtics vs. 76ers odds from SportsLine consensus, while the over/under for total points scored is 233.5. Before making any 76ers vs. Celtics picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past seven-plus seasons. The model enters Week 2 of the 2025-26 NBA season on a sizzling 161-120 roll on all top-rated NBA picks, returning nearly $4,000. It also went 24-11 (69%) on top-rated NBA against-the-spread picks last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Celtics vs. 76ers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Celtics vs. 76ers:

Why the 76ers can cover

Veteran guard Tyrese Maxey powers the Philadelphia offense. In four starts, he is averaging 37.5 points, 8.3 assists, 3.8 rebounds and one steal in 43 minutes. He is coming off a double-double in the win over the Wizards. In 47 minutes of action, he poured in 39 points, while adding 10 assists and three rebounds. He scored 43 points and added eight assists and four rebounds in a 136-124 win over Orlando on Monday.

Rookie guard VJ Edgecombe is off to a fast start to his career. In four starts, he is averaging 22.3 points, 5.8 rebounds, 5.5 assists and 1.5 steals in 40.3 minutes. In a 117-116 win at Boston in the season opener on Oct. 22, he poured in 34 points, while grabbing seven rebounds and dishing out three assists. He scored 26 points, while adding seven assists and four rebounds in the win over the Magic. See which team to back at SportsLine.

Why the Celtics can cover

With Jayson Tatum (Achilles) sidelined for an extended period, veteran guard Jaylen Brown has carried the load early this season. In five starts, he is averaging 26.8 points, 5.6 rebounds and 3.8 assists in 32.6 minutes. He is coming off a 30-point, five-rebound and four-assist performance in the win over Cleveland. He had 41 points, six rebounds and four assists in a 119-113 loss to the Detroit Pistons on Sunday.

Guard Derrick White has also been a big part of the Boston offense. In five starts, he is averaging 17 points, 4.4 assists, 3.8 rebounds, 1.4 steals and one block in 34.2 minutes. In the season-opening loss to the 76ers, he scored 25 points, while adding four assists and three rebounds. He had 19 points, five rebounds and four assists in the win over Cleveland. See which team to back at SportsLine. 

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How to make Celtics vs. 76ers picks

SportsLine's model has simulated Celtics vs. 76ers 10,000 times and is leaning Under the total, projecting 231 combined points. The model also says one side hits in well over 50% of simulations. You can head to SportsLine to see the model's NBA picks. 

So who wins Celtics vs. 76ers, and which side of the spread hits well over 50% of simulations? Visit SportsLine now to see which side of the Celtics vs. 76ers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.