Cavaliers vs. Pacers odds, prediction: 2025 NBA picks for Friday, November 21 from proven model

The Cleveland Cavaliers are set to play the Indiana Pacers in 2025 NBA Cup action on Friday. Both teams are in East Group A and the Cavs are 1-1 in NBA Cup play thus far, while the Pacers are 0-1. Cleveland is 10-6 overall, while Indiana is 2-13 as it has been decimated by injuries. Darius Garland (toe) and Jarrett Allen (finger) are listed as questionable for Cleveland. Tyrese Haliburton (Achilles), Aaron Nesmith (knee) and Obi Toppin (foot) are among the players still out for Indiana. This is a rematch of last year's Eastern Conference semifinals, a series Indiana won 4-1.

Tipoff is set for 7 p.m. ET in Cleveland. Cleveland is a 13.5-point road favorite in the latest Cavaliers vs. Pacers odds, while the over/under is 239.5. Before making any Pacers vs. Cavaliers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 5 of the 2025-26 NBA season on a sizzling 28-13 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Cavaliers vs. Pacers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Cavaliers vs. Pacers:

How to make Cavaliers vs. Pacers picks

SportsLine's model has simulated Pacers vs. Cavs 10,000 times and is going Under 239.5 combined points. Both sides have injury concerns, and three straight Cleveland games have gone Under the total. 

The model projects 233 combined points as the Under hits in nearly 60% of simulations.

The model also says one side of the spread hits nearly 70% of the time. You can head to SportsLine to see the model's NBA picks. 

So who wins Pacers vs. Cavs, and which side of the spread hits nearly 70% of the time? Visit SportsLine now to see which side of the spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.