NASCAR at Daytona predictions, lines, odds: 2025 Coke Zero Sugar 400 picks from model that called 27 winners

The conclusion of the 2025 NASCAR Cup Series regular season takes place on Saturday at the same spot the season began -- Daytona International Speedway. The 2025 Coke Zero Sugar 400 is the final race before the Cup Series Playoffs, with Kyle Busch, Alex Bowman, Tyler Reddick and Brad Keselowski among the drivers still searching for their first wins of the year. William Byron won the Daytona 500 to open the year and has already clinched the Cup Series regular season, but he's still just fifth on the 2025 NASCAR at Daytona odds board for the Coke Zero Sugar 400 2025.

Byron is at +700, trailing top favorites such as Joey Logano (+1000), Ryan Blaney (+1100) and Keselowski (+1200). Reddick is a +2700 NASCAR longshot at the Coke Zero Sugar 400 2025 to collect not only his first win of the year, but also his first Daytona victory. The green flag will drop at 7:30 p.m. ET for Saturday's race which will take place over 160 laps on the 2.5-miles tri-oval track. Blaney will start on the pole, which is his third pole position of the 2025 Cup Series. Before entering any 2025 Coke Zero Sugar 400 picks, be sure to see the latest 2025 NASCAR at Daytona predictions from SportsLine's proven projection model.

Developed by daily Fantasy pro and SportsLine predictive data engineer Mike McClure, this proprietary NASCAR prediction model simulates every race 10,000 times, taking into account factors such as track history and recent results.

McClure's model began the 2025 season by calling Chase Elliott's win in the Cook Out Clash at Bowman Gray for a +300 payout. Then it went on to predict Kyle Larson in Miami (+350), Christopher Bell's NASCAR All-Star Race win (+600), Denny Hamlin's win in Michigan (+650), Shane van Gisbergen's win in Mexico City (+330), Elliott's win in Atlanta (+1500) and van Gisbergen again in Chicago (+150), Sonoma (+125) and Watkins Glen (+135).

All told, the model has nailed nine winners this year and a whopping 27 winners since 2021. Anyone who followed its lead on betting apps and sportsbooks on those NASCAR picks could have seen huge returns. New users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

Now, the model simulated the 2025 Coke Zero Sugar 400 10,000 times. Head to SportsLine to see the complete projected NASCAR at Daytona leaderboard.

Top 2025 Coke Zero Sugar 400 predictions

For Saturday's 2025 Coke Zero Sugar 400, the model is high on Chris Buescher, even though he's a longshot at +1900 in the latest 2025 NASCAR at Daytona odds. In his 10th season as a full-time Cup Series driver, Buescher sits 11th in the standings, putting him in position to achieve just the second top-10 season finish of his career. His previous Daytona success should help with that goal as he won this very race two years ago. He overtook Kevin Harvick for the lead on the penultimate lap, and that's part of a string of impressive races for Buescher at Daytona International Speedway.

The native Texan has top 10s in four of his last five NASCAR Daytona starts, including earlier this year in the Daytona 500. Also, Buescher won the Bluegreen Vacations Duel at Daytona in 2022, which was an exhibition event run prior to The Great American Race. Buescher needs a victory to clinch a playoff spot, so that extra incentive makes him one to back with NASCAR Daytona bets. Find the best price at DraftKings, but also be sure check out the latest bet365 bonus code to get $200 in bonus bets after placing a $5 bet. 

The model has also revealed a shocking NASCAR prop for this weekend: Brad Keselowski finishes top 5 for a +145 payout. He's a potentially a strong value pick for your Daytona NASCAR prop bets. The veteran had a dreadful star to the year with zero top 10s across his first dozen races, but he's reversed course since then. He's notched eight top 10s over his last 13 starts, including in four of his last five races. He also has four top 5s over that span and had arguably his best race of the season earlier this month in Iowa. The 2012 Cup Series champion won both stages, had the fastest lap and finished in third place at Iowa Speedway.

Keselowski is among a dozen or so drivers in the Coke Zero Sugar 400 field who count themselves as past Daytona winners, courtesy of him winning this race in 2016. More recently, he was runner-up to teammate Buescher at this event in 2023, as RFK Racing finished 1-2. So, he clearly has the backing of a team that knows how to navigate this track, and that was one of four top 5s Keselowski's achieved at Daytona in his career. One also shouldn't discount the experience he brings to this circuit as just three active drivers have made more starts than Keselowski's 32 at Daytona. See which other drivers to back and the rest of the projected NASCAR leaderboard at SportsLine and new users can check out the latest FanDuel promo code and get $300 in bonus bets instantly at FanDuel if your $5 bet wins:

How to make 2025 NASCAR at Daytona picks

The model is also targeting two other drivers with Daytona NASCAR odds of 18-1 or longer to make a serious run at the checkered flag. Anyone who backs these drivers could hit it big. You can see all of the model's NASCAR picks, props, and projected leaderboard over at SportsLine.

So who wins the 2025 Coke Zero Sugar 400, and which longshots are must-backs? Check out the latest 2025 NASCAR at Daytona odds below, then visit SportsLine now to see the full NASCAR Daytona projected leaderboard, all from the model that has nailed 27 winners, and find out.

2025 NASCAR Daytona odds, drivers, lineup

See the full NASCAR at Daytona picks at SportsLine

(odds via DraftKings subject to change)

Joey Logano +1000
Ryan Blaney +1100
Brad Keselowski +1200
Austin Cindric +1400
Kyle Busch +1400
Chase Elliott +1600
Kyle Larson +1700
William Byron +1700
Chris Buescher +1900
Denny Hamlin +2000
Ryan Preece +2000
Alex Bowman +2000
Christopher Bell +2200
Bubba Wallace +2500
Carson Hocevar +2700
Ross Chastain +2700
Tyler Reddick +2700
Ricky Stenhouse Jr. +2700
Chase Briscoe +3000
Erik Jones +3000
Noah Gragson +4000
Todd Gilliland +4000
Justin Haley +4000
Michael McDowell +4000
Ty Gibbs +4500
Josh Berry +4500
Austin Dillon +4500
Ty Dillon +4500
Daniel Suarez +5000
John Hunter Nemechek +5500
Zane Smith +6000
AJ Allmendinger +6500
Austin Hill +8000
Shane van Gisbergen +8000
Cole Custer +8000
Riley Herbst +10000
Cody Ware +30000
Casey Mears +50000
Joey Gase +50000
B.J. McLeod +50000