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The Los Angeles Dodgers are amid their worst stretch of the season, having lost 10 of their last 12 games heading into their matchup against the Minnesota Twins during the Monday MLB schedule. Los Angeles was swept by Milwaukee over the weekend and has lost six straight home games, which is its longest home losing streak since 2017. Minnesota is coming off a 7-1 win over Colorado on Sunday and has split its last 10 games. The Twins are +146 underdogs in the Monday MLB odds, which is one of the longshots that SportsLine's model is targeting. 

All 30 teams in the majors are in action on Monday, and three teams are at least -190 favorites. Backing underdogs in any of those games could result in a solid payout. The biggest underdog, according to the latest MLB odds, is the White Sox, who are priced at +193 on the road against the Tampa Bay Rays. Before making any MLB picks or building any MLB parlays, you'll want to see the MLB predictions and betting advice from SportsLine's proven computer simulation model. Bet on every MLB game at DraftKings Sportsbook, where you can get $150 in bonus bets instantly with the latest DraftKings promo code:

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns. 

The model has broken down the MLB betting odds for Monday and just revealed its top MLB longshot picks. Combining the model's three picks into an MLB parlay at BetMGM Sportsbook would result in a payout of +1983 (risk $100 to win $1,983). New users can even take advantage of the BetMGM bonus code offering up to $1,500 in bonus bets if their first bet loses. Click here to claim the offer. 

Here are its best longshot bets for the MLB slate on Monday

  • Red Sox money line vs. Phillies (+180)
  • Christian Yelich to record an RBI (+210)
  • Twins money line vs. Dodgers (+146)
  • Combine these picks for a shot at a +1983 payout (odds subject to change)  

Red Sox money line vs. Phillies (+180)

Boston has been one of the hottest teams in the majors this month, winning 11 of its last 13 games. The Red Sox are coming off a 6-1 win over the Cubs on Sunday, as Wilyer Abreu homered twice and drove in three runs. Philadelphia has been trending in the opposite direction, with its 8-2 loss to the Angels on Sunday marking the team's eighth loss in 14 games this month. The Phillies have ace Zack Wheeler on the mound, but the model has Boston winning in 41% of simulations to provide value at this price.

Christian Yelich to record an RBI (+210)

Milwaukee is riding a 10-game winning streak following its 6-5 win over the Dodgers on Sunday, pulling into a tie with the Cubs atop the National League Central. Yelich leads the Brewers with a .259 batting average, 19 home runs and 65 RBIs, reaching safely in 11 of his last 13 games. He is facing Mariners starting pitcher George Kirby, who is 4-4 with a 4.50 ERA this season. The model has Yelich finishing with 0.6 RBIs in its latest simulations for this matchup, which makes the +210 prop worth wagering on.

Twins money line vs. Dodgers (+146)

Los Angeles might have Shohei Ohtani on the mound for this game, but the Dodgers are slumping heading into the series opener. They have lost 10 of their last 12 games and have been significantly overvalued by the betting market during that stretch. Ohtani is expected to pitch just three innings as the Dodgers ease him back into the rotation, so Minnesota will have plenty of opportunities to face other pitchers on Monday. Twins starter David Festa has won two of his last three starts, and the model has Minnesota winning in 41% of simulations to create value on this money line.

Want more MLB picks for today?

You've seen some of the model's MLB best longshot bets for Monday. Now, get run line, total and money-line picks for every game here, all from the model that's simulated every game 10,000 times. 

Also at SportsLine:
You can also see today's top MLB picks from expert Bruce Marshall, who's on a sizzling 55-45-1 roll on his last 101 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who's up over 15 units.