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The Los Angeles Dodgers will host the St. Louis Cardinals on Wednesday, and Shohei Ohtani will take the mound for the eighth time this season. He's pitched three innings in each of his last three starts, but it was only a hip cramp that caused his exit in his last outing, so there's potential for him to be stretched out considerably tonight. Meanwhile, the Cardinals will counter with Matthew Liberatore, who sports a 3.96 ERA over 109 innings this season.

First pitch from Dodger Stadium is set for 4:10 p.m. ET. Los Angeles is a -220 home favorite (risk $220 to win $100) in the latest Cardinals vs. Dodgers odds, while St. Louis is a +177 underdog (risk $100 to win $177). The over/under for total runs scored is 9.5. Ohtani's over/under for strikeouts thrown is 4.5. Before making any Dodgers vs. Cardinals picks, be sure to see the MLB betting predictions from SportsLine's proven model. Bet on Cardinals vs. Dodgers and every other MLB game at DraftKings, using the latest DraftKings promo code, which offers new users $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 20 of the 2025 MLB season 28-23 on top-rated MLB money-line picks. It has excelled in making home run prop picks this season, returning nearly 50 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns. Also, see the model's top home run picks and MLB prop picks for Wednesday.

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Here are the model's best bets for Dodgers vs. Cardinals on Wednesday:

Cardinals to win (+177)

Ohtani sports a 2.40 ERA over 15 innings this season, and the idea that he might be stretched into the fifth or even sixth inning here is deeply appealing, but it might be far-fetched. Los Angeles has been careful of their deployment of Ohtani, and he's 2-for-21 at the dish in his last five games when he's been the starting pitcher, so double-duty hasn't served him well. The Cardinals swiped a win in Game 1, and the model likes this price for them to steal another, predicting that they win in 39% of simulations.

Alec Burleson over 0.5 total bases (-179)

Burleson is coming off a 21-homer season in 2024, and he's been even better this year, slashing .278/.331/.450 entering Wednesday's action. He's recorded at least one total base in 68 of his 103 games this season, and that 66% hit rate on its own makes anything under -200 a win. He has an .828 OPS against right-handed pitching this season, and he should get multiple passes against righties with Ohtani on the mound and a somewhat shorthanded Dodgers bullpen to follow.

Want more MLB picks for Wednesday?

You've seen the model's MLB picks for Dodgers vs. Cardinals. Now, get every MLB pick from No. 1 expert Bruce Marshall, who is up more than 16 units on his last 1MLB picks.