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Kirk (hamstring) isn't practicing Wednesday, DJ Bien-Aime of ESPN.com reports.

A mid-week addition to the Week 7 injury report, Kirk was ruled out Saturday for Monday's eventual loss to Seattle (in which No. 1 receiver Nico Collins suffered a concussion). Houston may now be without both Kirk and Collins this Sunday against the 49ers, which would leave more routes/targets for some combination of Xavier Hutchinson, Jayden Higgins, Jaylin Noel and Braxton Berrios.

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