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Bye weeks and a long list of NFL injuries bring plenty of challenges for figuring out Week 6 Fantasy football rankings. Fantasy players already knew players such as Lamar Jackson, Brock Purdy, Chris Godwin and CeeDee Lamb would be out on Sunday. Ja'Marr Chase (illness) was a late addition to the injury report, though reports indicate he is trending towards playing. 

How should those injuries impact your Fantasy football picks, and which Fantasy football sleepers should be on your radar this week? Before making your Week 6 Fantasy football picks, be sure to check out the Week 6 Fantasy football rankings from the proven computer model at SportsLine. 

Bet on every NFL Week 6 game at DraftKings Sportsbook, where new users can target the DraftKings promo code, which offers $200 in bonus bets if your $5 initial wager wins:

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons, especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

The same model has a proven track record providing Fantasy football tips, including being ahead of the curve on players like A.J. Brown, Jonathan Taylor, Derrick Henry, Christian McCaffrey, Alvin Kamara and Jahmyr Gibbs. Anybody who banked on players like those could have made a run at their league title.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 6 of the 2025 NFL season. Head to SportsLine now to see them. 

New users can also check out the latest FanDuel promo code and get $300 in bonus bets instantly at FanDuel if your $5 bet wins. 

Top Week 6 Fantasy football picks 

One surprise in Week 6: The model is fading Lions quarterback Jared Goff, a two-time Pro Bowler who leads the NFL with 12 passing touchdowns. Goff ranks 10th in Fantasy points amongst quarterbacks this year, but much of his success came in two games against a pair of teams who rank in the bottom five in scoring defense in Cincinnati and Chicago. In Goff's other three contests, he's averaging just 198.3 passing yards with four total touchdowns and a pair of turnovers.

Detroit visits Kansas City on Sunday night in Week 6, and only three teams have allowed fewer passing touchdowns than the Chiefs. They're also top 10 in passing yards allowed, as only one opposing quarterback has had more touchdowns than interceptions versus Kansas City, which has held its last four opposing QBs to just 157.3 passing yards. Thus, Goff may not warrant a spot in Week 6 Fantasy football lineups as he sits outside the top 15 in positional rankings.

Another curveball: The model is high on Raiders wideout Tre Tucker. The third-year pro out of Cincinnati is coming off a 71-yard outing in Week 5 and has been one of the most surprising Fantasy players this season. He is the WR16 in PPR scoring and is the WR10 in standard leagues. Tucker is tied for the team lead with four touchdowns, and his 315 scrimmage yards top both Jakobi Meyers (290) and Brock Bowers (225) amongst Raiders' pass catchers.

Vegas takes on Tennessee on Sunday, and few defenses are as giving to wideouts as the Titans are. They allow the fifth-most receiving yards per game to opposing wide receivers, and just eight teams have given up more catches to the position. Tennessee has seen eight different opposing wideouts have at least 67 receiving yards or a touchdown versus the team this season, with three receivers reaching both of those thresholds. Tucker is slotted as a top-20 Fantasy wideout by the model in Week 6. For more start/sit Fantasy football advice, be sure to check out the rest of the Week 6 Fantasy football rankings.

New users can also target the latest Underdog promo code, good for $100 in site credits when you play $5 with the promo code CBSSPORTS2  in select states.

How to set Week 6 Fantasy football rankings

The model is also calling for a surprising running back you aren't even thinking about to finish in the top 15 of its Week 6 Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. See the model's entire Week 6 Fantasy football rankings for PPR and standard leagues here.

So who should you start and sit this week, and which surprising running back could lead you to victory? Visit SportsLine now to get Week 6 Fantasy football rankings for every position, plus see which running back is going to come out of nowhere to crack the top 15, all from the model that has outperformed experts big-time.