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Pearsall (knee) has been ruled out for Sunday's game at Houston, Nick Wagoner of ESPN.com reports.

Pearsall hasn't practiced since September and will now miss a fourth straight game. Meanwhile, 49ers head coach Kyle Shanahan said Friday that Brandon Aiyuk (ACL) may return to practice next week, per Eric Branch of the San Francisco Chronicle. For now, Jauan Jennings and Kendrick Bourne are the team's starting wide receivers.

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