San Francisco head coach Kyle Shanahan said Mitchell (shoulder) will play Sunday against Arizona, David Lombardi of The Athletic reports. Mitchell was a full participant in Friday's session after taking limited reps Wednesday and Thursday, according to Darren Urban of the Cardinals' official site.
Mitchell missed the 49ers' last two games with the right shoulder injury, allowing rookie Trey Sermon to get a look as the team's lead back. While Sermon bounced back from a poor showing in the Week 3 loss to the Packers with a more productive one (19 carries for 89 yards) last week against the Seahawks, he's still likely to lose at least some work to Mitchell, who briefly took over as the 49ers' top option out of the backfield following Raheem Mostert's (knee) season-ending injury in the opener. Though Mitchell absorbed contact in practices this week and looks healthy again, predicting how the work may break down between him and Sermon is difficult. Shahanan hasn't hinted whether Mitchell will immediately reclaim lead duties in the backfield, or if he'll be eased back into the mix as part of a timeshare with Sermon.