Holmes exited Wednesday's game against Sacramento in the first quarter with an an apparent injury and made a trip to the locker room, Varun Shankar of The Washington Post reports.
Holmes posted two points (1-1 FG) in two minutes before checking out of the contest with 1:09 remaining in the opening period. If Holmes is unable to return, Tristan Vukcevic would handle any backup minutes at center available behind Alex Sarr for the remainder of the contest.