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Chicago designated Cowles for assignment Monday.

Cowles will cede his spot on the 40-man roster to first baseman Carlos Santana, who was signed to a one-year contract. Acquired from the Yankees last summer, Cowles has yet to make his MLB debut, and his numbers have taken a hit in 2025 after he was added to the 40-man roster over the winter. Cowles has slashed .242/.306/.389 with nine home runs and 16 stolen bases while striking out at a 28.6 percent clip across 462 plate appearances with Iowa.

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