Week 10 college football odds, best bets: Top Wednesday college football picks, betting predictions on Oct. 29
Find Wednesday's best bets for the Week 10 college football schedule from the SportsLine Projection Model
The Wednesday night Conference USA college football takeover continues this week when the Middle Tennessee Blue Raiders host the Jacksonville State Gamecocks at 7:30 p.m. ET, and the Missouri State Bears host the Florida International Panthers at 8 p.m. ET, which will air on CBS Sports Network. Middle Tennessee is one of just two schools in the 12-team Conference USA without a conference victory this season, and the Blue Raiders will need to pull off an upset as 4.5-point underdogs to change that.
The SportsLine model doesn't like Middle Tennessee's odds of doing that, making Jacksonville State to cover the 4.5-point spread one of its Wednesday college football best bets. Jacksonville State is coming off a bye after defeating Delaware, 38-25, on Oct. 15. The model is backing one underdog, though, picking Florida International as a 3.5-point underdog in its Wednesday college football best bets when online sports betting.
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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it enters Week 10 on a profitable 47-33 combined run on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.
Best bets for Wednesday's college football schedule
- Jacksonville State (-4.5) vs. Middle Tennessee
- FIU (+3.5) to defeat Missouri State
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Wednesday college football best bets
- Game: Jacksonville State Gamecocks vs. Middle Tennessee Bears, 7:30 p.m. ET
- The Pick: Jacksonville State (-4.5)
Jacksonville State has scored more than 40 points against Middle Tennessee in back-to-back seasons, with a 42-20 victory last year and a 45-30 win the season before. Jacksonville State improved to 3-0 in Conference USA with a 38-25 win over Delaware on October 15, while Middle Tennessee lost to that same Delaware team, 31-28, last week. Jacksonville State has the leading rusher in college football, with Cam Cook rushing for 949 yards and 10 touchdowns this season. He's rushed for more than 115 yards in five of his last six games, and the model expects Cook to break 130 rushing yards on Wednesday. The model projects Jacksonville State to cover the spread in 75% of simulations.
- Game: Florida International Panthers vs. Missouri State Bears, 8 p.m. ET on CBS Sports Network
- The Pick: FIU (+3.5)
The Panthers are coming off a 45-26 loss to Kennesaw State last week, but Missouri State is a significantly different level of competition. Kennesaw State is the only 4-0 team in Conference USA this season, while Missouri State is 2-1 in the conference with uninspiring victories. The Bears had a two-point victory over Middle Tennessee, which is winless in the conference, and needed overtime to get past New Mexico State, which is 1-3 in Conference USA. Meanwhile, FIU handed Western Kentucky its only loss in conference play in a 25-6 final this season. FIU senior running back Kejon Owens has rushed for 361 yards over his last two games, and the model projects him to break 110 yards again on Wednesday. The model projects the Panthers to cover the spread in 57% of simulations.
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