Vanderbilt vs. Missouri prediction, odds: 2025 college football Week 9 picks from proven model

Quarterback Diego Pavia and the No. 10 Vanderbilt Commodores (6-1) and the No. 15 Missouri Tigers (6-1) square off in an SEC showdown on Saturday. The Commodores bounced back from a loss to Alabama and beat LSU 31-24 last week. Likewise, the Tigers come in fresh off a win, defeating Auburn 23-17 in double-overtime in Week 8. Both teams have a 5-2 mark against the spread this season.

Kickoff from FirstBank Stadium in Nashville, Tenn., is at 3:30 p.m. ET. The Commodores are 3-point favorites in the latest Missouri vs. Vanderbilt odds, while the over/under for total points scored is 53.5. Before making any Vanderbilt vs. Missouri picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 42-30 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Missouri vs. Vanderbilt. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Missouri vs. Vanderbilt:

Why Missouri can cover

Missouri's offense averages 39 points and an SEC high 244.9 rushing yards per game. Sophomore running back Ahmad Hardy leads the way, as he tops the SEC in rushing yards (840) and rushing touchdowns (11). The Mississippi native has gone over 100 rushing yards in five games this season.

Senior quarterback Beau Pribula has thrown for 1,617 yards and 11 scores. He added 210 rushing yards and another five touchdowns on the ground. Pribula has thrown for multiple touchdowns in four games this campaign. See which team to back at SportsLine. 

Why Vanderbilt can cover

Pavia, who is fourth in the latest Heisman Trophy odds at +650, is a dual-threat force who has completed 70% of his throws for 1,569 yards and 15 touchdowns. He also leads the team in rushing yards (438), and has an additional four rushing touchdowns. Last week against LSU, he had 160 passing yards, 82 rushing yards, and three total touchdowns. 

Junior running back Sedrick Alexander is another playmaker in the backfield who can get into the end zone, as he has a team-high six rushing scores. Defensively, Miles Capers has 18 total tackles and a team-high 4.5 sacks. The Commodores also enter this game 3-1 ATS as the home team. See which team to back at SportsLine.

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How to make Missouri vs. Vanderbilt picks

SportsLine's model is going Over on the total, projecting 61 combined points. It also says one side of the spread hits in well over 60% of simulations. You can only get the pick at SportsLine. 

So who wins Missouri vs. Vanderbilt, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the Missouri vs. Vanderbilt spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.