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Multiple Top 25 matchups will take place this weekend in college football. The No. 5 Ole Miss Rebels (6-0) and the No. 9 Georgia Bulldogs (5-1) square off in an SEC collision at 3:30 p.m. ET. Last weekend, the Rebels came away with a 24-21 win over Washington State. Georgia also handled business against Auburn, securing a 20-10 win on Oct. 11. According to the latest Week 8 CFB odds, the Bulldogs are 7.5-point favorites, while the over/under is 53.5 points. Our model is backing the Rebels to cover the spread (+7.5) in this contest. The model is taking the Over on total points (61.5) in the USC vs. Notre Dame game. In addition, the model takes the under on total points (58.5) in the Tennessee vs. Alabama matchup. Those CFB picks are part of a Top-25 parlay at FanDuel Sportsbook that pays over 5-1.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 39-27 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Three Saturday college football betting picks for CFB Week 8 (odds subject to change): 

  • Ole Miss (+7.5) vs. Georgia
  • USC vs. Notre Dame: Over 61.5 total points
  • Tennessee vs. Alabama: Under 61.5 total points

Combining the model's three picks into a college football parlay at FanDuel would result in a payout of +595 (risk $100 to win $595).

Ole Miss (+7.5) vs. Georgia (-110, FanDuel)

The Rebels are rolling, as they've won six straight games to start the season. Georgia has dominated this series in history, owning a 33-11-1 edge over Ole Miss, but the Rebels defeated the Bulldogs 28-10 last year. Going into this game, Georgia is 2-4 ATS as the favorite this season and 1-3 ATS when they get equal rest as their opponent. As for the Rebels, they have gone 4-2 ATS in all games and 2-1 ATS in conference games. SportsLine's model has Ole Miss covering the spread in 67% of simulations. 

USC vs. Notre Dame: Over 61.5 total points (-110, FanDuel)

USC is averaging 44.5 points per game this season. Junior quarterback Jayden Maiava has thrown for 1,852 passing yards with 13 passing touchdowns and only two interceptions. His main pass catcher is junior receiver Makai Lemon, who has 682 receiving yards and six scores. The Trojans have seen the over hit in four of their six games thus far. As for the Fighting Irish, they are putting up 40 points per game. Junior running back Jeremiyah Love has a team-high 530 rushing yards and eight touchdowns in 2025. Notre Dame had the over hit in the first four weeks of the campaign. SportsLine's model predicts these teams combine for 66 total points, with the over hitting in 58% of simulations.

Tennessee vs. Alabama: Under 61.5 total points (-110, FanDuel)

SEC games have a history of being gritty and defensive at times. These teams have scored fewer than 58 points in each of the last two games. The under hit in the Volunteers' last game, while the under hit in two of the last three outings for Alabama. SportsLine's model believes this trend continues and has the under hitting in 61% of simulations. They are projected to score 55 total points.