Oklahoma vs. Missouri prediction, odds, line, time: Week 13 college football picks by proven model

One of two ranked matchups in college football Week 13 is an SEC showdown on Saturday between No. 8 Oklahoma and No. 22 Missouri. The OU Sooners (8-2, 4-2 SEC) are coming off an upset of then-fourth ranked Alabama, 23-21, giving Oklahoma back-to-back road wins over ranked teams after defeating Tennessee in Week 10. The Mizzou Tigers (7-3, 3-3 SEC) ended a two-game losing streak with a 49-27 win over Mississippi State last Saturday. Missouri quarterback Beau Pribula (ankle) has been cleared to return for the Tigers. Oklahoma lists star defensive lineman R Mason Thomas as doubtful. 

Kickoff is at noon ET from Gaylord Family-Oklahoma Memorial Stadium in Norman, Okla. After opening at -6.5, the Sooners are now 5.5-point favorites in the latest Oklahoma vs. Missouri odds, while the over/under for total points scored is 42.5. Before making any Missouri vs. Oklahoma picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Missouri vs. Oklahoma. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Oklahoma vs. Missouri:

How to make Oklahoma vs. Missouri picks

SportsLine's model has simulated Missouri vs. Oklahoma 10,000 times and is going Over 42.5 total points. Each of the last six meetings between these teams has eclipsed not only 42.5 points, but also 52.5 points. Last year's matchup saw 53 combined points scored, and both squads have emphatically upgraded their offenses. 

OU added QB John Mateer, who was the Heisman favorite due to his dual-threat abilities before a hand injury sidelined him. Meanwhile, Mizzou added RB Ahmad Hardy, who leads the nation in rushing yards and ranks fourth, nationally, in touchdowns. SportsLine's advanced model forecasts 46 total points as the Over hits in well over 50% of simulations.

The model also says one side of the spread is the better value. You can only get the pick at SportsLine.   

So who wins Oklahoma vs. Mizzou, and which side of the spread is the better value? Visit SportsLine now to see which side of the Mizzou vs. Oklahoma spread to jump on, all from the advanced model that is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season, and find out.