Indiana vs. Penn State prediction, odds, line, time: Week 11 college football picks by proven model

The second-ranked Indiana Hoosiers will look to keep the Penn State Nittany Lions winless in Big Ten play when they meet on Saturday. Indiana is coming off a 55-10 win over Maryland, while Penn State dropped a 38-14 decision at Ohio State. The Hoosiers (9-0, 6-0 Big Ten), who lead the conference, are 3-0 on the road this season. The Nittany Lions (3-5, 0-5 Big Ten), who have lost five in a row, are 3-2 on their home field this year. Indiana senior wide receiver Elijah Sarratt's (hamstring) status is uncertain after missing last week's game.

Kickoff from Beaver Stadium in University Park, Pa., is at noon ET. Penn State leads the all-time series 25-2, including a 33-24 win in the last meeting in 2023. The Hoosiers are 14.5-point favorites in the latest Indiana vs. Penn State odds, while the over/under for total points scored is 50.5 via SportsLine consensus. Before making any Indiana vs. Penn State picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Indiana vs. Penn State. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Penn State vs. Indiana:

Why Indiana can cover

The Hoosiers are led by Heisman Trophy candidate Fernando Mendoza. The junior quarterback, who transferred from California, is in his first year with the program. In nine starts, he has completed 162 of 224 passes (72.3%) for 2,124 yards and 25 touchdowns with just four interceptions and a 153.3 rating. He has also rushed 50 times for 220 yards and four touchdowns. In a 38-13 win over Michigan State on Oct. 18, he completed 24 of 28 passes for 332 yards and four touchdowns.

Among his top pass catchers is junior wide receiver Omar Cooper Jr. In nine games, Cooper has 46 receptions for 669 yards (14.5 average) and eight touchdowns. He also has one 75-yard rushing touchdown in a 56-9 win over Kennesaw State. In the win over Michigan State, he caught eight passes for 115 yards and one touchdown. See which team to back at SportsLine. 

Why Penn State can cover

With senior quarterback Drew Allar out with a broken ankle, the Nittany Lions have turned to freshman quarterback Ethan Grunkemeyer. In parts of five games this season, he has completed 42 of 67 passes (62.7%) for 343 yards and one touchdown with three interceptions. He has also rushed for one score. In last week's loss at Ohio State, he completed 19 of 28 passes for 145 yards and one interception.

Senior running back Kaytron Allen powers the Penn State ground attack. In eight games, he has carried 119 times for 688 yards (5.8 average) and 10 touchdowns. He has also caught 12 passes for 43 yards. In a 25-24 loss at Iowa on Oct. 18, he carried 28 times for 145 yards and two touchdowns. He rushed eight times for 50 yards and two scores in a 42-37 loss at UCLA on Oct. 4. See which team to back at SportsLine.

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How to make Indiana vs. Penn State picks

SportsLine's model is going Over on the total, projecting 51 combined points. It also says one side of the spread hits in well over 60% of simulations. You can only get the pick at SportsLine. 

So who wins Penn State vs. Indiana, and which side of the spread hits in well over 60% of the time? Visit SportsLine now to see which side of the Indiana vs. Penn State spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.