Colorado vs. Iowa State prediction, odds, spread: 2025 college football Week 7 picks, prop bets by top expert

The Colorado Buffaloes (2-4) are set to host the No. 22 Iowa State Cyclones (5-1) in a Big 12 showdown on Saturday. The Buffs are in their third season under head coach Deion Sanders, and enter this matchup looking for their first win in Big 12 play in 2025. CU is looking to bounce back from its 35-21 loss to TCU in its last outing. Iowa State has its sights set on contending in the Big 12 and making a run at a spot in the College Football Playoff. The Cyclones will be looking to rebound from their 38-30 loss to Cincinnati on Oct. 4. Iowa State is 3-2-1, while CU is 3-3 against the spread in 2025.

Kickoff from Folsom Field in Boulder, Colo. is set for 3:30 p.m. ET. The Cyclones are 3-point favorites in the latest Iowa State vs. Colorado odds, while the over/under for total points scored is 51.5. Before making any Colorado vs. Iowa State picks, make sure you check out what SportsLine college football expert Jimmie Kaylor has to say. 

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Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 249-175-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 99.84 units ($9,983.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has zoned in on Colorado vs. Iowa State and just locked in his picks and CFB predictions. You can head to SportsLine now to see his picks. Here are several college football odds and college football betting lines for Iowa State vs. CU:

Why Iowa State can cover

The Cyclones entered the 2025 season with high expectations, and have gotten off to a 5-1 start. Iowa State's lone loss came last week against Cincinnati, but the team remains nationally ranked at No. 22 in the AP Top-25 Poll. Head coach Matt Campbell is in his 10th season on the job and boast a 69-52 overall record during his time leading the program.

Quarterback Rocco Becht remains the centerpiece of the Cyclones' offense that is averaging over 31 points per game in 2025. The 6-foot-1 junior completed 271 of 456 passes for 3,505 yards and 25 touchdowns and nine interceptions while adding eight rushing scores in 2024. In 2025, Becht has thrown for 1,417 yards, nine touchdowns, and two interceptions, and rushed for 55 yards and seven scores. See which team to back at SportsLine. 

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Why Colorado can cover

The Buffs are in their third season under head coach Deion Sanders and continue to work toward building consistency in Big 12 play. Quarterback Kaidon Salter, a transfer from Liberty, has taken over the offense and thrown for 901 yards, seven touchdowns, and four interceptions through six games. Running back Micah Welch leads the ground attack with 250 rushing yards, while wideout Omarion Miller has emerged as the top target with 289 receiving yards and three touchdowns. 

On defense, cornerback DJ McKinney has provided steady play in the secondary, recording the team's lone interception, and the Buffaloes have tallied eight sacks as a team so far this season. Through six games, Colorado holds a 2–4 record overall and 0–3 in Big 12 play, averaging 25.0 points per game while allowing 24.8. Despite the record, the Buffaloes have shown flashes of progress with a young roster and new playmakers on both sides of the ball. See which team to back at SportsLine.

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How to make Colorado vs. Iowa State picks

For Saturday's Iowa State vs. CU matchup, Kaylor is leaning Under on the point total, but he also says a critical X-factor makes one side of the spread a must-back. You can only see what it is, and which side to back, at SportsLine. 

Who covers in Colorado vs. Iowa State, and what critical x-factor do you need to know about? Visit SportsLine now to see which side of the Iowa State vs. Colorado spread you need to jump, all from the expert who returned $9,984 to $100 players since the start of the 2023 season, and find out.