College football picks, Week 13 predictions by proven expert: This parlay returns almost +600
Thomas Casale has locked in his top three college football picks for Week 13 and his CFB parlay could pay out nearly +600

College Football Playoff contenders such as Ohio State, Georgia, Alabama, Texas A&M and Notre Dame are all gigantic favorites against overmatched opponents during the Week 13 college football schedule. Even with all those mismatches on the slate, there are still some games that are loaded with playoff implications. Perhaps the biggest is No. 7 Oregon vs. No. 15 USC (CBS/Paramount+) in what could serve as a playoff play-in game. The latest college football odds list the Ducks as 10.5-point favorites.
The eighth-ranked Oklahoma Sooners are also hanging on to their playoff hopes, and they play No. 22 Missouri, who will have quarterback Beau Pribula (ankle) available. Oklahoma is -5.5 in that matchup. No. 20 Tennessee (-3.5) vs. Florida, No. 18 Michigan (-14.5) vs. Maryland and No. 16 Georgia Tech (-2.5) vs. Pitt are among the other notable Week 13 college football lines.
Before locking in any Week 13 college football picks, be sure to see the top Week 13 college football expert picks, predictions and best bets from Thomas Casale.
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A frequent guest on national radio and TV shows to discuss college sports, Casale has been sports betting -- and winning -- for more than 30 years.
Now, he has turned his attention to the Week 13 college football odds and is sharing his top betting picks. If you parlay these college football betting picks, you could be looking at a return of nearly +600. Get his top college football picks at SportsLine.
Top Week 13 college football expert predictions
One of Casale's top Week 13 college football picks: He's going Over 59.5 points in Oregon vs. USC at 3:30 p.m. ET.
"This matchup just screams points," Casale told SportsLine. "The last 10 meetings between USC and Oregon have produced at least 54 points with eight going over 60. I think we will see another high-scoring game on Saturday. The issue USC faces is it struggles to stop the run. The Trojans are allowing close to 170 rushing yards in their last three games. When the Ducks are able to run the football, it sets up everything else they do offensively and lets quarterback Dante Moore make big plays down the field. If Oregon gets the running game going early on Saturday, USC's defense is in for a long day.
"On the other side, USC is the most explosive offense the Ducks have faced, including Indiana. The Trojans have a little more speed at receiver than the Hoosiers. While Oregon has a really good front seven on defense, the Hoosiers put up 30 points on them. That was really the only good offense Oregon has faced all season, so the Ducks'' defensive stats could be a little overrated." See what other college football picks Casale likes at SportsLine, and bet that line right here:
How to make Week 13 college football picks
Casale has found two other college football picks he loves, including backing a big underdog that "has a chance to steal a win." You can only see his picks at SportsLine, and you can use promo code CHAMPIONSHIP to get your first month at SportsLine for just $1.
What are the best bets for Week 13 of college football, and which underdog should you back? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper, and find out.
















