2025 college football picks, Week 7 odds, predictions by proven expert: This parlay returns +600
Thomas Casale has locked in his top three college football picks for Week 7 and his CFB parlay could pay out around +600
The Week 7 college football schedule continues on Saturday with a must-see lineup that is anchored by a top-10 matchup between Oregon and Indiana at 3:30 p.m. ET on CBS and Paramount+. The latest Week 7 college football odds list the Ducks as 7-point favorites in that one, which has major College Football Playoff implications.
Other Week 7 college football lines of note include Alabama (-3.5) vs. Missouri, USC (-2.5) vs. Michigan and the Red River Rivalry between Texas and Oklahoma (-1). OU quarterback John Mateer has been upgraded to probable, setting up a showdown against Texas quarterback Arch Manning. Before locking in any Week 7 college football picks on those game or others, be sure to see the top Week 7 college football expert picks, predictions and best bets from Thomas Casale.
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A frequent guest on national radio and TV shows to discuss college sports, Casale has been sports betting -- and winning -- for more than 30 years. After going 11-9 so far this season, including a 3-0 sweep in Week 4, he's on a 24-15 roll in his SportsLine best bets column that dates back to last season. Anybody who followed him could have been way up.
Now, he has turned his attention to the Week 7 college football odds and is sharing his top betting picks. If you parlay these college football betting picks, you could be looking at a return of around +600. Get his top college football picks at SportsLine.
Top Week 7 college football expert predictions
One of Casale's top Week 7 college football picks: He's going Over (53.5) in the Oregon vs. Indiana matchup at 3:30 p.m. ET on CBS and Paramount+.
"I expect this to be a fun game between what looks like two of the Big Ten's top three teams," Casale told SportsLine. "Oregon's offense started slowly at Penn State but I think that was by design with Dante Moore making his first huge road start in front of 110,000 people. Look for Oregon to be more aggressive offensively in this game at home, especially early. Indiana hasn't faced an offense close to this good all season and I expect the Hoosiers to struggle with Oregon's elite speed at the skill positions. If Indiana is going to keep pace in this game, they will need to score with the Ducks.
"Curt Cignetti is one of the best coaches in the country, although I thought he played a little conservative early on in losses to Ohio State and Notre Dame last season. This is just a hunch, but I think we see Cignetti be much more aggressive here in the underdog role to try and put pressure on Oregon." See what other college football picks Casale likes at SportsLine.
How to make Week 7 college football picks
Casale has found two other college football picks he loves, including backing a shocking underdog that could win outright against a team "in an awful spot." You can only see his picks at SportsLine, and you can use promo code CHAMPIONSHIP to get your first month at SportsLine for just $1.
What are the best bets for Week 7 of college football, and which surprising underdog could win outright? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper who is on a 25-14 roll on CFB best bets, and find out.
