Alabama vs. South Carolina prediction, odds, line, time: 2025 college football Week 9 picks by proven model

The fourth-ranked Alabama Crimson Tide will look to stay unbeaten in SEC action when they take on the South Carolina Gamecocks on Saturday. Alabama is coming off a 37-20 win over Tennessee in Week 8, while South Carolina was beaten 26-7 by Oklahoma. The Crimson Tide (6-1, 4-0 SEC), who have won six in a row, are 2-1 on the road this season. The Gamecocks (3-4, 1-4 SEC), who have lost two straight, are 2-2 on their home field in 2025. Alabama has ruled out six players and lists offensive lineman Geno VanDeMark as probable. South Carolina has ruled out offensive lineman Cason Henry.

Kickoff from Williams-Brice Stadium in Columbia, S.C., is at 3:30 p.m. ET. The Crimson Tide are 11.5-point favorites in the latest Alabama vs. South Carolina odds, while the over/under for total points scored is 47.5 via SportsLine consensus. Before making any South Carolina vs. Alabama picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 42-30 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Alabama vs. South Carolina. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for South Carolina vs. Alabama:

Why Alabama can cover

Junior Ty Simpson is one of college football's best quarterbacks. In seven games this season, he has completed 153 of 218 passes (70.2%) for 1,931 yards and 18 touchdowns with just one interception and a rating of 170.9. He has also rushed 45 times for 66 yards and two scores. In a 30-14 win over Vanderbilt on Oct. 4, he completed 23 of 31 passes for 340 yards and two touchdowns with one interception.

Among his top targets is senior wide receiver Germie Bernard. In seven games, he has 33 receptions for 472 yards (14.3 average) and five touchdowns. In a 73-0 win over Louisiana-Monroe, he caught three passes for 67 yards and two scores. He caught five passes for 82 yards and one touchdown in the win over Vanderbilt. See which team to back at SportsLine. 

Why South Carolina can cover

Sophomore quarterback LaNorris Sellers helps power the Gamecocks' offense. For the season, he has completed 90 of 139 passes (64.7%) for 1,134 yards and five touchdowns and two interceptions with a rating of 142.3. He also has carried 84 times for 108 yards and one touchdown. In a 29-20 loss at Missouri on Sept. 20, he completed 18 of 28 passes for 302 yards and two touchdowns.

Sophomore Vandrevius Jacobs is South Carolina's top receiver. He leads the Gamecocks with 21 receptions for 343 yards (16.3 average) and two touchdowns. In a 29-20 loss at Missouri on Sept. 20, he caught seven passes for 128 yards and one touchdown. He had five catches for 108 yards, including a long of 59, in a 35-13 win over Kentucky on Sept. 27. See which team to back at SportsLine.

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How to make Alabama vs. South Carolina picks

SportsLine's model is going Under on the total, projecting 43 combined points. It also says one side of the spread hits in well over 50% of simulations. You can only get the pick at SportsLine. 

So who wins Alabama vs. South Carolina, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Alabama vs. South Carolina spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.