Kentucky vs. Louisville odds, prediction, line, time: 2025 college basketball picks for Nov. 11 from model

Heavyweights clash when the ninth-ranked Kentucky Wildcats take on the No. 12 Louisville Cardinals in the 58th edition of the Battle of the Bluegrass on Tuesday night. Kentucky is coming off a 107-59 win over Valparaiso on Friday, while Louisville downed Jackson State 106-70 on Thursday. The Wildcats (2-0), who tied for sixth in the SEC a year ago at 10-8 and were 24-12 overall, are 4-6 on the road since the start of last season. The Cardinals (2-0), who tied for second in the ACC at 18-2 and were 27-8 overall in 2024-25, are 16-3 on their home court since last November.

Tipoff from KFC Yum! Center in Louisville, Ky., is set for 8 p.m. ET. Kentucky leads the all-time series 40-17, including a 14-10 edge in games played at Louisville. Louisville is a 4.5-point favorite in the latest Kentucky vs. Louisville odds from SportsLine consensus, while the over/under for total points scored is 175.5. Before making any Louisville vs. Kentucky picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Kentucky vs. Louisville 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for Louisville vs. Kentucky:

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How to make Kentucky vs. Louisville picks

SportsLine's model is going Under on the total. The Wildcats have gone Under the total in five of the last six games, while the Cardinals have been Under in six of their past 10. The model also has just three Kentucky players scoring in double figures, led by Otega Oweh with an average simulation total of 13.1 points. 

The model says Louisville has five players in double digits, led by Adrian Wooley's 17 points. The teams combine for 162 points as the Under hits in 80% of simulations.. You can head to SportsLine to see the model's men's college basketball picks. 

So who wins Kentucky vs. Louisville, and which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Kentucky vs. Louisville spread to back, all from the advanced model was profitable on top-ranked college basketball picks last season, and find out.