Kansas vs. Duke odds, prediction: 2025 Champions Classic picks from proven model

Blue-blood programs clash when the 24th-ranked Kansas Jayhawks battle the fifth-ranked Duke Blue Devils at the 2025 Champions Classic on Tuesday night. Kansas is coming off a 76-57 win over Princeton on Saturday, while Duke downed Indiana State 100-62 on Friday. The Jayhawks (3-1), who have won two in a row, are 0-1 against ranked opponents this season. The Blue Devils (4-0), who are 3-0 on neutral courts, are 8-6 in the Champions Classic all-time.

Tipoff from Madison Square Garden in New York is set for 9 p.m. ET. Duke leads the all-time series 8-7, but Kansas holds a 7-6 edge in games played at neutral sites. Duke is an 11.5-point favorite in the latest Kansas vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 148.5. Before making any Duke vs. Kansas picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Kansas vs. Duke 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for Duke vs. Kansas:

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How to make Kansas vs. Duke picks

SportsLine's model is going Over on the total (148.5 points). The Blue Devils have shown the ability to post some massive offensive numbers as they've averaged more than 100 points in their past three outings.

Kansas played a high-scoring game against North Carolina earlier this season that surpassed the total, and the model has found value on the Over now that the line has dropped below 150 total points.

The model also says one side of the spread hits in more than 50% of simulations. You can head to SportsLine to see the model's men's college basketball picks. 

So who wins Kansas vs. Duke, and which side of the spread hits in more than 50% of simulations? Visit SportsLine now to see which side of the Kansas vs. Duke spread to back, all from the advanced model was profitable on top-ranked college basketball picks last season, and find out.