College basketball odds, picks, best bets for Friday, Nov. 7: This 3-leg computer parlay returns nearly +600

The 2025-26 college basketball schedule continues on Friday, Nov. 7, including nine games involving ranked teams. The most intriguing game of the day pits No. 19 Kansas against No. 25 North Carolina. It is the Jayhawks' first-ever visit to Chapel Hill. The game from the Dean E. Smith Center is set to tip off at 7 p.m. ET. The Tar Heels are the 1.5-point favorites in the latest college basketball odds for Friday, with the over/under at 157.5.

Other college basketball lines of note include Georgetown vs. Maryland (-6.5), Valparaiso vs. Kentucky (-33.5) and Detroit vs. Notre Dame (-20.5). With a lot of early-season mismatches on the board, what are the college basketball best bets for Friday? Before locking in any college basketball picks, you'll want to see the college basketball predictions and betting advice from SportsLine's proven computer model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has scoured the latest college basketball odds and locked in three confident college basketball picks. If you successfully parlay its college basketball betting picks, you'd be looking at a payout of just under +600. You can only see the model's college basketball picks at SportsLine.

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Top college basketball picks for Friday, Nov. 7

After simulating every game 10,000 times, the model is backing George Mason (-11.5) to cover against Winthrop in a 7 p.m. ET tip at EagleBank Arena in Fairfax, Va. George Mason opened its season with a 70-46 win over Wofford on Monday night. Junior guard Kory Mincy led the Patriots with game highs in points (18) and assists (6). He was 6 of 9 from the floor, including 4 of 5 on 3-pointers. Winthrop, meanwhile, defeated Queens 81-74 on Monday.

SportsLine's model projects that this game will not be as close as some expect, and likes George Mason to easily cover the spread in 70% of simulations. See which other college basketball parlay picks to make here, and bet this pick right here:

How to make college basketball predictions for Friday, Nov. 7

The model also has locked in two other picks, including one in the huge Kansas vs. North Carolina matchup that hits well over 60% of the time. You can only see the model's college basketball parlay at SportsLine.

What are the model's top college basketball parlay picks for Friday, and which best bets should you target for a chance at a payout of nearly +600. Visit SportsLine now to see college basketball best bets from a model that was profitable on top-rated picks last year, and find out.