College basketball odds, picks, bets: This parlay returns +1100 on Wednesday

After 10,000 simulations, SportsLine's model reveals its top college basketball picks today

By Ross Kelly

Nov 12, 2025 at 11:56 am ET • 3 min read

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The 2025-26 college basketball schedule continues on Wednesday, Nov. 12, with over 50 games involving Division I teams. Two contests feature ranked teams in action with No. 1 Houston vs. Oakland (+28.5) and No. 12 Tennessee vs. North Florida (+40.5). The Cougars will play their first game as the top-ranked team after leapfrogging Purdue in the AP Poll, while the Volunteers, who are amongst the biggest favorites per the college basketball odds, will take on the Ospreys for the first time ever.

Other college basketball lines of note include Minnesota vs. Missouri (-6.5), Marquette vs. Little Rock (+20.5) and Oregon vs. South Dakota State (+16.5). With just two games under most teams' belts and little data to go off, what are the Wednesday college basketball best bets to pursue for a CBB parlay? Before locking in any college basketball picks, you'll want to see the college basketball predictions and betting advice from SportsLine's proven computer model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has scoured the latest college basketball odds and locked in three confident college basketball picks. If you successfully parlay its college basketball betting picks, you'd be looking at a payout of nearly +1100. You can only see the model's college basketball picks at SportsLine.

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Top college basketball picks for Wednesday, Nov. 12

After simulating every game 10,000 times, the model is backing Saint Joseph's (+10.5) to cover on the road versus Virginia Tech at 7 p.m. ET. It was less than a year ago that these two programs faced off at a neutral site, with St. Joe's notching a 20-point blowout victory. The Hawks have won the last two meetings with the Hokies, both coming away from home, so they will have confidence in going into Blacksburg, Va.

Both teams have started this season 2-0, but Virginia Tech has a recent history of letting down after a victory. The team is just 4-10 against the spread following a victory since the start of last season, and St. Joe's has the firepower to stick within this double-digit spread, with the team led by Deuce Jones II. The sophomore paces the team with 15.5 points after winning A-10 Rookie of the Year honors last year with La Salle. He's one of four Hawks averaging at least 11.5 points, while the Hokies' defense is penetrable as it allowed 101 points to Providence on Saturday.

SportsLine's model projects this game to be decided by a single possession, as Saint Joseph's (+10.5) covers in almost 70% of simulations. See which other college basketball parlay picks to make here, and bet this pick right here: