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The 2025-26 college basketball schedule continues on Monday, Nov. 10, including three games involving ranked teams. The most intriguing game of the day pits Santa Clara against Xavier. Santa Clara has opened the season 1-1, while Xavier is off to a 2-0 start. The game from Cintas Center in Cincinnati is set to tip off at 8:30 p.m. ET. The Musketeers are the 2.5-point favorites in the latest college basketball odds for Monday, with the over/under at 157.5.

Other college basketball lines of note include Mississippi State vs. No. 16 Iowa State (-5.5) and Cal State Fullerton vs. California (-22.5). With a lot of early-season mismatches on the board, what are the college basketball best bets for Monday? Before locking in any college basketball picks, you'll want to see the college basketball predictions and betting advice from SportsLine's proven computer model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has scoured the latest college basketball odds and locked in three confident college basketball picks. If you successfully parlay its college basketball betting picks, you'd be looking at a payout of over +600. You can only see the model's college basketball picks at SportsLine.

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Top college basketball picks for Monday, Nov. 10

After simulating every game 10,000 times, the model is backing UNC-Wilmington (+2.5) to cover against Kent State in a 7 p.m. ET tip at Memorial A&C Center in Kent, Ohio. UNC-Wilmington opened its season with a 106-77 win over Mount Olive, while Kent State opened with a 103-97 loss to Troy, before rebounding with a 110-102 win over Cornell on Friday. Senior guard Nolan Hodge led the Seahawks with 21 points, connecting on 4 of 6 3-pointers. Senior guard Morgan Safford powers the Golden Flashes, averaging 27.5 points over the first two games.

SportsLine's model projects that this game will not go as some expect, and likes UNC-Wilmington to easily cover the spread in nearly 80% of simulations. See which other college basketball parlay picks to make here, and bet this pick right here:

How to make college basketball predictions for Monday, Nov. 10

The model also has locked in two other picks, including one in the Santa Clara vs. Xavier matchup that hits over 60% of the time. You can only see the model's college basketball parlay at SportsLine.

What are the model's top college basketball parlay picks for Monday, and which best bets should you target for a chance at a payout of over +600. Visit SportsLine now to see college basketball best bets from a model that was profitable on top-rated picks last year, and find out.